Institut Universitaire en Santé Mentale de Québec, Québec, QC G1J 2G3, Canada; Department of Mathematics and Statistics, Université Laval, Québec, QC G1V 0A6, Canada.
Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix Marseille Université, F-13385 Marseille, France.
Neuron. 2016 Mar 16;89(6):1157-1172. doi: 10.1016/j.neuron.2016.02.030.
Fast synaptic inhibition relies on tight regulation of intracellular Cl(-). Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of Cl(-) dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales. This dynamical perspective helps explain many unintuitive manifestations of Cl(-) dysregulation. Here we discuss how taking into account dynamical regulation of intracellular Cl(-) is important for understanding how synaptic inhibition fails, how to best detect that failure, why Cl(-) regulation is energetically so expensive, and the overall consequences for therapeutics.
快速的突触抑制依赖于细胞内氯离子 (Cl(-)) 的紧密调节。氯离子失调与几种神经和精神疾病有关。氯离子失调的后果不仅仅是去抑制，而是涉及多个过程在许多时空尺度上进行复杂相互作用的动态系统，从这个角度来看，可以更好地理解其多方面的后果。这种动态观点有助于解释氯离子失调的许多非直观表现。在这里，我们讨论了考虑细胞内氯离子的动态调节对于理解突触抑制失败的原因、如何最好地检测到这种失败、为什么氯离子调节如此昂贵以及对治疗的整体影响的重要性。
Zotero 插件