大气压下酚类与二氧化碳的羧基化反应。

Carboxylation of Phenols with CO2 at Atmospheric Pressure.

作者信息

Luo Junfei, Preciado Sara, Xie Pan, Larrosa Igor

机构信息

School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.

出版信息

Chemistry. 2016 May 10;22(20):6798-802. doi: 10.1002/chem.201601114. Epub 2016 Mar 31.

DOI:10.1002/chem.201601114

PMID:26989848

Abstract

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2 . The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.

摘要

已开发出一种在常压二氧化碳压力下对苯酚进行邻位羧基化的便捷高效方法。该方法为先前报道的需要非常高二氧化碳压力的科尔贝 - 施密特方法提供了一种替代方案。事实证明，添加三取代苯酚对于在标准大气压下用二氧化碳成功羧基化苯酚至关重要，从而能够高效制备多种水杨酸。