溃疡性结肠炎患者白细胞介素-22的基因多态性
Genetic polymorphisms of interleukin-22 in patients with ulcerative colitis.
作者信息
Yamamoto-Furusho J K, Sánchez-Morales G E, García-Rangel D, Vargas-Alarcón G
机构信息
Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
出版信息
Rev Gastroenterol Mex. 2016 Apr-Jun;81(2):86-90. doi: 10.1016/j.rgmx.2016.02.002. Epub 2016 Mar 16.
BACKGROUND
Ulcerative colitis (UC) is a multifactorial and polygenic disease. Interleukin-22 (IL-22) is an immunomodulatory cytokine that belongs to the IL-10 family. Currently, some IL-22 polymorphisms have been associated with inflammatory processes such as rheumatoid arthritis and psoriasis vulgaris, but there are no studies on UC.
AIM
The aim of this work was to study the frequency of polymorphisms of IL-22 in Mexican patients with UC.
METHODS
We studied a total of 199 Mexican patients with confirmed UC and 697 healthy controls. All individuals were born in Mexico, at least three family generations earlier. A blood sample was obtained from the UC patients and healthy controls in order to perform DNA extraction and then to determine the frequency of IL-22 polymorphisms (rs2227485, rs2272478, rs2227491).
RESULTS
No statistical significance was found in the gene and genotype frequencies of three SNPs of IL-22 (rs2227485, rs2272478, rs2227491) between the UC patients and healthy controls. No association was found between those IL-22 SNPs and clinical features of UC.
CONCLUSIONS
There was no association between IL-22 SNPs (rs2227485, rs2272478, rs2227491) and the development of UC in a Mexican population.
背景
溃疡性结肠炎（UC）是一种多因素和多基因疾病。白细胞介素-22（IL-22）是一种属于IL-10家族的免疫调节细胞因子。目前，一些IL-22多态性已与类风湿性关节炎和寻常型银屑病等炎症过程相关，但尚无关于UC的研究。
目的
本研究旨在探讨墨西哥UC患者中IL-22基因多态性的频率。
方法
我们共研究了199例确诊为UC的墨西哥患者和697例健康对照。所有个体均出生于墨西哥，至少三代前。从UC患者和健康对照中采集血样，进行DNA提取，然后确定IL-22多态性（rs2227485、rs2272478、rs2227491）的频率。
结果
UC患者和健康对照之间，IL-22的三个单核苷酸多态性（rs2227485、rs2272478、rs2227491）的基因和基因型频率无统计学意义。未发现这些IL-22单核苷酸多态性与UC的临床特征之间存在关联。
结论
在墨西哥人群中，IL-22单核苷酸多态性（rs2227485、rs2272478、rs2227491）与UC的发生无关联。
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