Mooyaart Eline A Q, Gelderman Egbert L G, Nijsten Maarten W, de Vos Ronald, Hirner J Manfred, de Lange Dylan W, Leuvenink Henri D G, van den Bergh Walter M
Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Resuscitation. 2016 Jun;103:1-6. doi: 10.1016/j.resuscitation.2016.03.012. Epub 2016 Mar 18.
Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.
The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.
From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.
Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.
人体硫化氢（H₂S）中毒常伴有致命后果。在小动物模型中，硫化氢已显示出对缺氧具有显著的保护作用。尚未发表聚焦于其对人类潜在保护作用的报告。
描述了一大群硫化氢中毒患者的发生频率及转归情况。
1980年至2013年期间，共发生35起事故，涉及56名受害者，其中至少24人（43%）存活。在现场有记录进行心肺复苏的8名患者中，6人（75%）存活。在一些转归良好的病例中，在被解救和复苏前暴露于极高硫化氢水平的时间超过45分钟。
与粪便相关的硫化氢中毒死亡率很高，尽管在某些情况下，恢复情况似乎比最初表现所显示的要好得多。可能是硫化氢诱导类似假死状态从而对缺氧性损伤起到保护作用。
