Hengen Keith B, Torrado Pacheco Alejandro, McGregor James N, Van Hooser Stephen D, Turrigiano Gina G
Department of Biology, Brandeis University, Waltham, MA 02454, USA.
Department of Biology, Brandeis University, Waltham, MA 02454, USA.
Cell. 2016 Mar 24;165(1):180-191. doi: 10.1016/j.cell.2016.01.046. Epub 2016 Mar 17.
Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms. PAPERCLIP.
稳态机制通过将放电率维持在设定点范围内来稳定神经回路功能，但这一过程是否受脑状态的调控尚不清楚。在这里，我们监测了自由活动大鼠在睡眠和清醒状态之间循环时，单个视觉皮层神经元的放电率稳态。当神经元放电率因视觉剥夺而受到干扰时，它们在活跃清醒期间会逐渐恢复到精确的、细胞自主的设定点，清醒期的延长会增强放电率的反弹。出乎意料的是，睡眠期间神经元放电的这种重置受到抑制。这增加了记忆巩固或其他依赖睡眠的过程容易受到稳态可塑性机制干扰的可能性。回形针。
