噻吗洛尔半水合物0.5%溶液每日一次或两次与山梨酸中马来酸噻吗洛尔的舒适度调查
A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate.
作者信息
Stewart William C, Oehler Jeffrey C, Choplin Neil T, Markoff Joseph I, Moster Marlene R, Ichhpujani Parul, Nelson Lindsay A
机构信息
Cofounder and Medical Director, PRN Pharmaceutical Research Network, LLC, Cheyenne Wyoming, USA.
Consultant, Northwest Eye Surgeons, Columbus, Ohio, USA.
出版信息
J Curr Glaucoma Pract. 2013 Jan-Apr;7(1):11-6. doi: 10.5005/jp-journals-10008-1130. Epub 2013 Jan 15.
OBJECTIVE
To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.
DESIGN
A prospective, multicenter, observational, non-interventional study.
PARTICIPANTS
One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice daily) or timolol maleate with potassium sorbate once daily as monotherapy or as a part of two-drug therapy.
MATERIALS AND METHODS
Study was performed at seven clinical sites in the United States. Patients were surveyed on comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.
RESULTS
A difference between timolol hemihydrate and timolol maleate with potassium sorbate for questions 1 (burning/stinging on instillation, p < 0.001) and 4 (tearing on instillation, p = 0.024) was noted. There were no differences between treatment groups for any other question (p > 0.05).
CONCLUSION
This survey suggests that timolol hemihydrate is associated with less stinging/burning and tearing than timolol maleate with potassium sorbate. How to cite this article: Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate. J Current Glau Prac 2013;7(1):11-16.
目的
通过调查评估与含有山梨酸钾的马来酸噻吗洛尔相比，半水合噻吗洛尔滴眼时的舒适度。
设计
一项前瞻性、多中心、观察性、非干预性研究。
参与者
103例年龄≥21岁的开角型青光眼或高眼压症患者，他们目前正在接受半水合噻吗洛尔（每日一次或两次）或含有山梨酸钾的马来酸噻吗洛尔每日一次单药治疗或作为两药联合治疗的一部分。
材料与方法
研究在美国的七个临床地点进行。对患者进行调查，比较半水合噻吗洛尔与含有山梨酸钾的马来酸噻吗洛尔滴眼时的舒适度。
结果
对于问题1（滴眼时烧灼感/刺痛感，p<0.001）和问题4（滴眼时流泪，p = 0.024），半水合噻吗洛尔与含有山梨酸钾的马来酸噻吗洛尔之间存在差异。治疗组在任何其他问题上均无差异（p>0.05）。
结论
该调查表明，与含有山梨酸钾的马来酸噻吗洛尔相比，半水合噻吗洛尔引起的刺痛/烧灼感和流泪较少。如何引用本文：Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. 每日一次或两次使用0.5%半水合噻吗洛尔溶液与马来酸噻吗洛尔在山梨酸盐中的舒适度调查。《青光眼当前实践杂志》2013年；7(1):11 - 16。
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