钙通道阻滞剂对眼压的影响。

Effect of calcium channel blockers on intraocular pressure.

作者信息

Payne L J, Slagle T M, Cheeks L T, Green K

机构信息

Department of Ophthalmology, Medical College of Georgia, Augusta.

出版信息

Ophthalmic Res. 1990;22(6):337-41. doi: 10.1159/000267044.

DOI:10.1159/000267044

PMID:2089345

Abstract

We determined the effects of either topical or systemic calcium channel antagonists on rabbit intraocular pressure (IOP). Topical nifedipine, verapamil or diltiazem had no significant effect on IOP. Intravenous verapamil and nifedipine caused statistically significant reductions in IOP between 2 and 6 h after administration; the nifedipine response followed an increase in IOP at 30 min. Diltiazem, given 3 times daily for 3 days, caused no pressure change. In the rabbit, therefore, calcium channel antagonists have no effect when given topically, but do reduce IOP when given systemically.

摘要

我们确定了局部或全身应用钙通道拮抗剂对兔眼内压（IOP）的影响。局部应用硝苯地平、维拉帕米或地尔硫䓬对眼内压无显著影响。静脉注射维拉帕米和硝苯地平在给药后2至6小时导致眼内压有统计学意义的降低；硝苯地平的反应在给药30分钟后眼内压升高之后出现。地尔硫䓬每日给药3次，连续给药3天，未引起眼压变化。因此，在兔中，钙通道拮抗剂局部给药时无作用，但全身给药时可降低眼内压。