Wang Zijian, Xiong Wei, Pan Cizhong, Zhu Liang, Wang Xinjun, Huang Zhichao, Zhao Xiaokun, Zhong Zhaohui
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Exp Ther Med. 2016 Mar;11(3):985-987. doi: 10.3892/etm.2016.3012. Epub 2016 Jan 20.
The present study reports an unusual case of high-grade bladder cancer in a 10-year-old girl who complained of painless hematuria and urinary frequency. The tumor displayed sarcomatoid differentiation and an aggressive behavior, which required the administration of adjuvant chemotherapy. However, the disease progressed and the patient succumbed 6 months after surgery. It is known that the majority of malignant bladder cancers in pediatric patients are low-grade and present at an early stage, whereas sarcomatoid differentiation in the setting of a high-grade urothelial carcinoma is indicative of a poor prognosis. It is important that gross hematuria in pediatric patients is investigated carefully. It is recommended that the management of urothelial neoplasia in young patients should be predominantly decided on the basis of the grade and stage of the tumor rather than the age of the patient.
本研究报告了一例罕见的10岁女童高级别膀胱癌病例，该女童主诉无痛性血尿和尿频。肿瘤表现出肉瘤样分化且具有侵袭性，需要进行辅助化疗。然而，疾病仍进展，患者术后6个月死亡。已知大多数儿科患者的恶性膀胱癌为低级别且处于早期，而高级别尿路上皮癌出现肉瘤样分化提示预后不良。仔细调查儿科患者的肉眼血尿很重要。建议年轻患者尿路上皮肿瘤的治疗主要应根据肿瘤的分级和分期来决定，而非患者年龄。
