Mikami Toshinari, Miake Yasuo, Bologna-Molina Ronell, Takeda Yasunori
Associate Professor, Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Iwate, Japan.
Associate Professor, Department of Histology and Developmental Biology, Tokyo Dental College, Tokyo, Japan.
J Oral Maxillofac Surg. 2016 Aug;74(8):1584-95. doi: 10.1016/j.joms.2016.02.016. Epub 2016 Feb 26.
Osteopetrosis is a generic term for generalized sclerotic conditions caused by rare genetic disorders. Decreased osteoclastic activities disturb bone remodeling, resulting in greater mineral density and greater compressive strength; therefore, bone fracture is a major physical symptom of osteopetrosis. Osteomyelitis of the maxilla or mandible is a common and well-documented complication of osteopetrosis. Local infection, such as odontogenic infection, is more likely to lead to osteomyelitis, and treatment strategies can be challenging. However, detailed ultrastructural analyses of bone from patients with osteopetrosis and odontogenic infection are limited. This report describes a case of osteomyelitis of the maxilla and mandible secondary to osteopetrosis in an adult patient and presents ultrastructural data of alveolar bone tissue analyzed by contact microradiography, electron probe microanalysis, and x-ray diffraction. Cases of osteomyelitis of the jaw secondary to osteopetrosis also are reviewed.
骨质石化症是由罕见遗传疾病引起的全身性硬化病症的统称。破骨细胞活性降低会干扰骨重塑，导致更高的矿物质密度和更大的抗压强度；因此，骨折是骨质石化症的主要身体症状。上颌骨或下颌骨骨髓炎是骨质石化症常见且有充分文献记载的并发症。局部感染，如牙源性感染，更易导致骨髓炎，且治疗策略颇具挑战性。然而，对患有骨质石化症和牙源性感染患者的骨骼进行详细超微结构分析的研究有限。本报告描述了一名成年患者因骨质石化症继发上颌骨和下颌骨骨髓炎的病例，并展示了通过接触式微放射摄影、电子探针微分析和X射线衍射分析的牙槽骨组织超微结构数据。还对骨质石化症继发颌骨骨髓炎的病例进行了综述。
