Walker Michael G, Jarman Paul J, Gill Martin R, Tian Xiaohe, Ahmad Haslina, Reddy Pattubala A N, McKenzie Luke, Weinstein Julia A, Meijer Anthony J H M, Battaglia Giuseppe, Smythe Carl G W, Thomas Jim A
Department of Chemistry, University of Sheffield, Sheffield, S10 3GZ, UK.
Department of Biomedical Science, University of Sheffield, Sheffield, UK.
Chemistry. 2016 Apr 18;22(17):5996-6000. doi: 10.1002/chem.201600852. Epub 2016 Mar 22.
Although metal-ion-directed self-assembly has been widely used to construct a vast number of macrocycles and cages, it is only recently that the biological properties of these systems have begun to be explored. However, up until now, none of these studies have involved intrinsically photoexcitable self-assembled structures. Herein we report the first metallomacrocycle that functions as an intracellular singlet oxygen sensitizer. Not only does this Ru2 Re2 system possess potent photocytotoxicity at light fluences below those used for current medically employed systems, it offers an entirely new paradigm for the construction of sensitizers for photodynamic therapy.
尽管金属离子导向的自组装已被广泛用于构建大量的大环和笼状结构，但直到最近这些体系的生物学性质才开始得到探索。然而，到目前为止，这些研究均未涉及具有内在光激发性的自组装结构。在此，我们报道了首个作为细胞内单线态氧敏化剂发挥作用的金属大环。这个Ru2Re2体系不仅在低于当前医学应用体系所使用的光通量下具有强大的光细胞毒性，还为光动力疗法敏化剂的构建提供了全新的范例。
