Wang Ying, Yang Hai-Bo
a Department of Otolaryngology , the First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China ;
b Department of Internal Medicine , the First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China.
Acta Otolaryngol. 2016 Aug;136(8):860-3. doi: 10.3109/00016489.2016.1157730. Epub 2016 Mar 22.
Idiopathic bronchiectasis is closely associated with chronic rhino-sinusitis. It can effectively control bronchiectasic symptoms to treat chronic rhino-sinusitis by FESS in the cases with bronchiectasis and chronic rhino-sinusitis.
To explore the effect of functional endoscopic sinus surgery (FESS) on the treatment of bronchiectasis combined with chronic rhino-sinusitis.
In this study, a total of 161 cases with bronchiectasis and chronic rhino-sinusitis were divided into medication group and operation group according to the therapeutic method for chronic rhino-sinusitis selected by them. For the treatment of chronic rhino-sinusitis, the cases in the operation group received FESS, but in the medication group cases took drugs alone. The score of clinical symptoms for bronchiectasis, forced expiratory volume in one second (FEV1), SNOT-22 score, and Lund-Mackay score were evaluated for all cases before and after treatment, respectively, and then the value changes in the score of clinical symptoms, FEV1, SNOT-22 score, and Lund-Mackay score between both time points were calculated. The frequency of acute exacerbation for bronchiectasis was also recorded within the 6-month follow-up.
In this study, 58.9% of cases with bronchiectasis had chronic rhino-sinusitis. Follow-up lasted 6 months. Compared with pre-therapy, post-therapy score of clinical symptoms, SNOT-22 score, and Lund-Mackay score were all significantly decreased (all p < 0.05), but post-therapy FEV1 failed to significantly improve (p > 0.05) in both groups. During the 6-month follow-up, the frequency of acute exacerbation was significantly less in the operation group than in the medication group (p < 0.01). Post-treatment score of clinical symptoms (p < 0.01), SNOT-22 score (p < 0.05), and Lund-Mackay score (p < 0.05) also were all significantly less in the operation group than in the medication group. However, there was no significant difference in post-therapy FEV1 between the two groups (p > 0.05).
特发性支气管扩张与慢性鼻-鼻窦炎密切相关。对于合并支气管扩张和慢性鼻-鼻窦炎的病例，通过功能性鼻内镜鼻窦手术（FESS）治疗慢性鼻-鼻窦炎可有效控制支气管扩张症状。
探讨功能性鼻内镜鼻窦手术（FESS）治疗支气管扩张合并慢性鼻-鼻窦炎的效果。
本研究共纳入161例支气管扩张合并慢性鼻-鼻窦炎患者，根据其选择的慢性鼻-鼻窦炎治疗方法分为药物治疗组和手术治疗组。手术治疗组针对慢性鼻-鼻窦炎采用FESS治疗，而药物治疗组仅采用药物治疗。分别在治疗前后评估所有患者支气管扩张的临床症状评分、一秒用力呼气容积（FEV1）、SNOT-22评分和Lund-Mackay评分，然后计算两个时间点之间临床症状评分、FEV1、SNOT-22评分和Lund-Mackay评分的变化值。在6个月的随访期内还记录了支气管扩张急性加重的频率。
本研究中，58.9%的支气管扩张患者患有慢性鼻-鼻窦炎。随访持续6个月。与治疗前相比，两组治疗后临床症状评分、SNOT-22评分和Lund-Mackay评分均显著降低（均p < 0.05），但两组治疗后FEV1均未显著改善（p > 0.05）。在6个月的随访期内，手术治疗组支气管扩张急性加重的频率显著低于药物治疗组（p < 0.01）。手术治疗组治疗后的临床症状评分（p < 0.01）、SNOT-22评分（p < 0.05）和Lund-Mackay评分（p < 0.05）也均显著低于药物治疗组。然而，两组治疗后FEV1无显著差异（p > 0.05）。
