Makhlouf Hoda Ahmed, Sadek Samiaa Hamdy, Nafady Asmaa Abdel Hakim
Department of Chest, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.
Clin Respir J. 2018 Jan;12(1):48-56. doi: 10.1111/crj.12477. Epub 2016 May 3.
The effect of association between chronic obstructive pulmonary disease (COPD) and diabetes (DM) on platelet function has not been studied before.
To evaluate the effect of the association between COPD and DM on platelet function and C reactive protein (CRP).
This case control study was carried out on 110 stable COPD patients who were classified into diabetic and nondiabetic groups. In addition, 40 apparently healthy, age and sex-matched individuals were included in this study as a control group. Chest X-ray, pulmonary function testing and arterial blood gases were done for COPD patients. CRP and complete blood count (CBC) were measured in both patient and control groups.
Mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and CRP were significantly higher in COPD patients either nondiabetic or diabetic compared to control group. Moreover, MPV and CRP markers were significantly higher in COPD diabetic patients compared to nondiabetic. There was no significant difference in various laboratory data among different stages of COPD either diabetic or nondiabetic (P > 0.05). In COPD patients, MPV was a significantly positively correlated with CRP and PDW (r = 0.346, P < 0.001; r = 0.510, P < 0.001, respectively) and negatively correlated with PLT count (r = -0.294, P = 0.002).
MPV, PDW, PCT and CRP were significantly higher in COPD patients either nondiabetic or diabetic. Platelet function may be modified by the systemic inflammation that associated with COPD. Platelet activation as a prothrombotic sequence of this disease may be used as novel therapeutic target.
慢性阻塞性肺疾病（COPD）与糖尿病（DM）之间的关联对血小板功能的影响此前尚未得到研究。
评估COPD与DM之间的关联对血小板功能和C反应蛋白（CRP）的影响。
本病例对照研究针对110例稳定期COPD患者展开，这些患者被分为糖尿病组和非糖尿病组。此外，40名年龄和性别匹配的明显健康个体被纳入本研究作为对照组。对COPD患者进行了胸部X线检查、肺功能测试和动脉血气分析。在患者组和对照组中均测量了CRP和全血细胞计数（CBC）。
与对照组相比，非糖尿病或糖尿病的COPD患者的平均血小板体积（MPV）、血小板分布宽度（PDW）、血小板压积（PCT）和CRP均显著更高。此外，COPD糖尿病患者的MPV和CRP标志物显著高于非糖尿病患者。糖尿病或非糖尿病的COPD不同阶段之间的各种实验室数据无显著差异（P>0.05）。在COPD患者中，MPV与CRP和PDW显著正相关（r = 0.346，P < 0.001；r = 0.510，P < 0.001），与血小板计数（PLT）负相关（r = -0.294，P = 0.002）。
非糖尿病或糖尿病的COPD患者的MPV、PDW、PCT和CRP均显著更高。与COPD相关的全身炎症可能会改变血小板功能。作为该疾病促血栓形成序列的血小板活化可能用作新的治疗靶点。
