Citirik M, Beyazyildiz E, Simsek M, Beyazyildiz O, Haznedaroglu I C
SB Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
Department of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Eye (Lond). 2015 Mar;29(3):376-9. doi: 10.1038/eye.2014.298. Epub 2014 Dec 19.
To search subclinical platelet activation via detecting three important platelet activation parameters; mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in diabetic retinopathy (DR) in comparison with those in healthy adults as controls.
This prospective study included 140 patients who were followed-up at the Ankara Ulucanlar Eye Education and Research Hospital, and 40 normal subjects. All patients and control subjects underwent complete ophthalmologic evaluation. Of patients with type 2 diabetes, 43 cases with diabetes mellitus (DM) have no DR (Group 1), 45 cases with DM have nonproliferative DR (NPDR) (Group 2), and 52 cases with DM have proliferative DR (PDR) (Group 3). In addition, 40 age- and sex-matched healthy controls (Group 4) were included into the study. MPV, PDW, and PCT were measured in the studied groups.
The MPV levels were significantly altered in Group 1, Group 2, and Group 3 patients when compared with those in the controls (P<0.05), whereas PDW and PCT levels were not significantly changed among groups (P>0.05).
The data provided a significant association between MPV levels and DM. Diabetic patients have increased MPV values compared with healthy subjects, but MPV levels were not altered together with the DR stage. Diabetic and DR patients have no different PDW and PCT values compared with healthy subjects. MPV may be a clue for the reflection of subclinical platelet activation in DM regardless of the DR stage.
通过检测糖尿病视网膜病变（DR）患者的三个重要血小板活化参数：平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板压积（PCT），与健康成年人作为对照进行比较，以探寻亚临床血小板活化情况。
这项前瞻性研究纳入了在安卡拉乌鲁坎拉尔眼科教育与研究医院接受随访的140例患者以及40例正常受试者。所有患者和对照受试者均接受了全面的眼科评估。在2型糖尿病患者中，43例糖尿病（DM）患者无DR（第1组），45例DM患者有非增殖性DR（NPDR）（第2组），52例DM患者有增殖性DR（PDR）（第3组）。此外，40例年龄和性别匹配的健康对照者（第4组）被纳入研究。对研究组测量了MPV、PDW和PCT。
与对照组相比，第1组、第2组和第3组患者的MPV水平有显著改变（P<0.05），而组间PDW和PCT水平无显著变化（P>0.05）。
数据表明MPV水平与DM之间存在显著关联。与健康受试者相比，糖尿病患者的MPV值升高，但MPV水平并未随DR分期而改变。与健康受试者相比，糖尿病和DR患者的PDW和PCT值无差异。无论DR分期如何，MPV可能是反映DM中亚临床血小板活化的一个线索。
