Du Kuo, Jaeschke Hartmut
Kuo Du, Hartmut Jaeschke, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States.
World J Gastroenterol. 2016 Mar 21;22(11):3302-4. doi: 10.3748/wjg.v22.i11.3302.
Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against acetaminophen hepatotoxicity and promote liver regeneration in a rodent model through alleviating the inflammatory response. However, several concerns exist regarding the limitations of the experimental design and interpretation of the data presented in this manuscript.
近年来，对包括中药在内的天然产物对乙酰氨基酚肝毒性影响的研究颇受关注，其中一些研究显示出了积极成果，甚至具有可观的治疗潜力。最近一份报告表明，六味五灵片在啮齿动物模型中可通过减轻炎症反应来预防对乙酰氨基酚肝毒性并促进肝脏再生。然而，对于该手稿中实验设计的局限性和所呈现数据的解读存在一些问题。
