波兰血脂异常的患病率。2011年波兰全国动脉粥样硬化预防项目（NATPOL）调查

Prevalence of lipid abnormalities in Poland. The NATPOL 2011 survey.

作者信息

Zdrojewski Tomasz, Solnica Bogdan, Cybulska Barbara, Bandosz Piotr, Rutkowski Marcin, Stokwiszewski Jakub, Gaciong Zbigniew, Banach Maciej, Wojtyniak Bogdan, Pencina Michael, Wyrzykowski Bogdan

机构信息

Zakład Prewencji i Dydaktyki, Gdański Uniwersytet Medyczny oraz Zakład Centrum Monitorowania i Analiz Stanu Zdrowia Ludności, Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny, Warszawa.

出版信息

Kardiol Pol. 2016;74(3):213-23. doi: 10.5603/KP.2016.0029.

DOI:10.5603/KP.2016.0029

PMID:27004543

Abstract

BACKGROUND

Poland represents a country of high cardiovascular (CV) risk. The association between lipid abnormalities and increased CV risk is well established. Therefore, it is important to monitor the prevalence and control of dyslipidaemia.

AIM

To evaluate serum lipids concentrations as well as the prevalence, awareness, and control of lipid abnormalities in a representative sample of adults in Poland.

METHODS

In 2011, in a national cross-sectional survey blood samples were collected from 1168 males and 1245 females, aged 18-79 years, for measurement of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG) in blood serum. Low density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.

RESULTS

Mean serum TC concentration was 197.1 mg/dL (95% CI 193.8-200.4) in males (M) and 198.6 mg/dL (95% CI 195.7-201.5) in females (F). Levels of LDL-C were 123.6 mg/dL (120.9-126.2) and 123.7 mg/dL (121.4-126.1), HDL-C - 45.8 mg/dL (44.7-47.0) and 54.1 mg/dL (53.1-55.1), TG - 140.9 mg/dL (133.0-148.8) and 104.0 mg/dL (99.8-108.2) for males and females, respectively. TC ≥ 190 mg/dL was found in 54.3% subjects (M 54.3%; F 54.4%). After adding patients on lipid-lowering treatment, hypercholesterolaemia was present in 61.1% of adults (M 60.8%; F 61.3%). LDL-C ≥ 115 mg/dL was detected in 57.8% of all subjects (M 58.3%; F 57.3%), while HDL-C < 40 mg/dL in 35.2% of males and < 45 mg/dL in 22% of females TG ≥ 150 mg/dL was found in 21.1% of subjects (M 28.4%; F 14.0%). The highest prevalence of elevated TC and LDL-C levels was present in the age group of 40-59-year-olds. Of those with hypercholesterolaemia 58.7% (M 61.5%, F 56.0%) were not aware of the condition; 22.0% (M 21.0%, F 24.5%) were aware but were not being treated; 8.1% (M 7.7%, F 8.5%) were treated but with TC ≥ 190 mg/dL; and only 10.9% (M 10.7%, F 11.0%) were being treated with TC < 190 mg/dL.

CONCLUSIONS

The prevalence of dyslipidaemia in Poland continues to be high--over 60% of adults have hypercholesterolaemia, and control remains poor. The results of the NATPOL 2011 survey call for urgent preventive measures.

摘要

背景

波兰是心血管疾病（CV）高风险国家。脂质异常与心血管疾病风险增加之间的关联已得到充分证实。因此，监测血脂异常的患病率和控制情况非常重要。

目的

评估波兰成年代表性样本中的血脂浓度以及脂质异常的患病率、知晓率和控制情况。

方法

2011年，在一项全国横断面调查中，收集了1168名年龄在18 - 79岁的男性和1245名女性的血样，用于测定血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL - C）和甘油三酯（TG）。低密度脂蛋白胆固醇（LDL - C）采用Friedewald公式计算。

结果

男性血清TC平均浓度为197.1mg/dL（95%CI 193.8 - 200.4），女性为198.6mg/dL（95%CI 195.7 - 201.5）。男性和女性的LDL - C水平分别为123.6mg/dL（120.9 - 126.2）和123.7mg/dL（121.4 - 126.1），HDL - C分别为45.8mg/dL（44.7 - 47.0）和54.1mg/dL（53.1 - 55.1），TG分别为140.9mg/dL（133.0 - 148.8）和104.0mg/dL（99.8 - 108.2）。54.3%的受试者TC≥190mg/dL（男性54.3%；女性54.4%）。纳入接受降脂治疗的患者后，61.1%的成年人患有高胆固醇血症（男性60.8%；女性61.3%）。57.8%的受试者LDL - C≥115mg/dL（男性58.3%；女性57.3%），35.2%的男性HDL - C<40mg/dL，22%的女性HDL - C<45mg/dL，21.1%的受试者TG≥150mg/dL（男性28.4%；女性14.0%）。40 - 59岁年龄组的TC和LDL - C水平升高患病率最高。在患有高胆固醇血症的人群中，58.7%（男性61.5%，女性56.0%）不知道自己的病情；22.0%（男性21.0%，女性24.5%）知道但未接受治疗；8.1%（男性7.7%，女性8.5%）接受了治疗但TC≥190mg/dL；只有10.9%（男性10.7%，女性11.0%）接受治疗后TC<190mg/dL。