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异染色质调控的新见解

New Insights into the Regulation of Heterochromatin.

作者信息

Wang Jiyong, Jia Sharon T, Jia Songtao

机构信息

Department of Biological Sciences, Columbia University, New York, NY, USA.

Department of Biological Sciences, Columbia University, New York, NY, USA.

出版信息

Trends Genet. 2016 May;32(5):284-294. doi: 10.1016/j.tig.2016.02.005. Epub 2016 Mar 20.

DOI:10.1016/j.tig.2016.02.005
PMID:27005444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4842111/
Abstract

All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this review we discuss the mechanism of constitutive heterochromatin assembly, its dynamic nature, and its responses to environmental changes.

摘要

所有生物都不断受到来自内部生物过程和周围环境的压力，这些压力会在细胞生理和基因表达程序中引发许多适应性变化。出乎意料的是，通常与基因沉默的稳定维持相关的组成型异染色质，也会响应刺激而受到动态调控。在这篇综述中，我们讨论了组成型异染色质组装的机制、其动态性质以及它对环境变化的反应。

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本文引用的文献

1
H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein.在缺乏异染色质蛋白1（HP1）的情况下，组蛋白H3赖氨酸9（H3K9）甲基化跨越异染色质的天然边界。
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Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.衰老干细胞。一种沃纳综合征干细胞模型揭示了异染色质改变是人类衰老的驱动因素。
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Elife. 2015 Mar 16;4:e06179. doi: 10.7554/eLife.06179.
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Heritable capture of heterochromatin dynamics in Saccharomyces cerevisiae.酿酒酵母中异染色质动力学的可遗传捕获。
Elife. 2015 Jan 12;4:e05007. doi: 10.7554/eLife.05007.
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RNA-mediated epigenetic regulation of gene expression.RNA 介导的基因表达表观遗传调控。
Nat Rev Genet. 2015 Feb;16(2):71-84. doi: 10.1038/nrg3863. Epub 2015 Jan 2.
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N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.HP1α的N端磷酸化增加了其核小体结合特异性。
Nucleic Acids Res. 2014 Nov 10;42(20):12498-511. doi: 10.1093/nar/gku995. Epub 2014 Oct 20.
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Chromosome boundary elements and regulation of heterochromatin spreading.染色体边界元件与异染色质扩展的调控
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Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells.衰老过程中的染色质维持与动态变化：聚焦衰老相关异染色质聚集体（SAHF）的形成及衰老细胞的表观基因组
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