异染色质调控的新见解
New Insights into the Regulation of Heterochromatin.
作者信息
Wang Jiyong, Jia Sharon T, Jia Songtao
机构信息
Department of Biological Sciences, Columbia University, New York, NY, USA.
Department of Biological Sciences, Columbia University, New York, NY, USA.
出版信息
Trends Genet. 2016 May;32(5):284-294. doi: 10.1016/j.tig.2016.02.005. Epub 2016 Mar 20.
Abstract
All living organisms are constantly exposed to stresses from internal biological processes and surrounding environments, which induce many adaptive changes in cellular physiology and gene expression programs. Unexpectedly, constitutive heterochromatin, which is generally associated with the stable maintenance of gene silencing, is also dynamically regulated in response to stimuli. In this review we discuss the mechanism of constitutive heterochromatin assembly, its dynamic nature, and its responses to environmental changes.
摘要
所有生物都不断受到来自内部生物过程和周围环境的压力，这些压力会在细胞生理和基因表达程序中引发许多适应性变化。出乎意料的是，通常与基因沉默的稳定维持相关的组成型异染色质，也会响应刺激而受到动态调控。在这篇综述中，我们讨论了组成型异染色质组装的机制、其动态性质以及它对环境变化的反应。
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