Hu Yulian, Gui Linyan, Chang Jing, Liu Jingyan, Xu Shuling, Deng Caiyan, Yu Fengqin, Ma Zhanmin, Wang Guangzhou, Zhang Changjun
Neonatal Department, Maternal and Child Health Hospital of Zhengzhou City, Zhengzhou City, Henan Province, China.
Pak J Pharm Sci. 2016 Jan;29(1 Suppl):321-3.
This study was to research the incidence of infants with rotavirus enteritis combined with lactose intolerance and the clinical effect of low lactose milk powder for infantile rotavirus enteritis with lactose intolerance. The control groups were 126 cases of infants with diarrhea randomly collected from our hospital at the same period, which their rotavirus detection was negative. The observation group was 185 cases of infants with rotavirus, which was tested to be positive. Through the urine galactose determination, 62 cases of the control group were positive and 124 cases of the observation group were positive. Then 124 cases of infants with rotavirus combined with lactose intolerance were randomly divided into two groups. 60 cases in the control group were given rehydration, correction of acidosis, oral smecta, Intestinal probiotics and other conventional treatment, then continued to the original feeding method. While, 64 cases in the treatment group, on the basis of routine treatment, applied the low lactose milk feeding. To observe the total effective rate for the two groups. The incidence of lactose intolerance in children with rotavirus enteritis (67.03%) was significantly higher than that of children with diarrhea (49.2%), which was tested to be negative. And the difference was statistically significant (p<0.5). In the aspect of reducing the frequency of diarrhea, and diarrhea stool forming time, the treatment group has the obvious superiority. The total effective rate was 95.4% for treatment group, which was higher than that in the control group (76.7%), the difference was statistically significant (P<0.05).
Infants with rotavirus enteritis was easier to merge with lactose intolerance. The low lactose milk powder could improve the therapeutic effectively and could reduce the duration of disease, and restored to normal diet for 2 weeks feeding time.
本研究旨在探讨轮状病毒肠炎合并乳糖不耐受婴儿的发生率以及低乳糖奶粉对婴儿轮状病毒肠炎合并乳糖不耐受的临床疗效。对照组为同期我院随机收集的126例腹泻婴儿，其轮状病毒检测为阴性。观察组为185例轮状病毒检测呈阳性的婴儿。通过尿半乳糖测定，对照组62例呈阳性，观察组124例呈阳性。然后将124例轮状病毒合并乳糖不耐受的婴儿随机分为两组。对照组60例给予补液、纠正酸中毒、口服蒙脱石散、肠道益生菌等常规治疗，然后继续原喂养方式。而治疗组64例，在常规治疗基础上，采用低乳糖牛奶喂养。观察两组的总有效率。轮状病毒肠炎患儿乳糖不耐受的发生率（67.03%）明显高于腹泻检测为阴性的患儿（49.2%）。差异有统计学意义（p<0.5）。在减少腹泻频率和腹泻大便成形时间方面，治疗组具有明显优势。治疗组总有效率为95.4%，高于对照组（76.7%），差异有统计学意义（P<0.05）。
轮状病毒肠炎婴儿更容易合并乳糖不耐受。低乳糖奶粉能有效提高治疗效果，缩短病程，且在喂养2周后可恢复正常饮食。
