Costa Letícia D, Costa Joana I T, Tomé Augusto C
Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal.
Molecules. 2016 Mar 9;21(3):320. doi: 10.3390/molecules21030320.
In recent years, several synthetic strategies aiming at the peripheral functionalization of porphyrins were developed. Particularly interesting are those involving the modification of β-pyrrolic positions leading to pyrrole-modified porphyrins containing four-, five-, six- or seven-membered heterocycles. Azeteoporphyrins, porpholactones and morpholinoporphyrins are representative examples of such porphyrinoids. These porphyrin derivatives have recently gained an increasing interest due to their potential application in PDT, as multimodal imaging contrast agents, NIR-absorbing dyes, optical sensors for oxygen, cyanide, hypochlorite and pH, and in catalysis.
近年来，人们开发了几种旨在实现卟啉外周功能化的合成策略。特别有趣的是那些涉及β-吡咯位置修饰的策略，从而得到含有四元、五元、六元或七元杂环的吡咯修饰卟啉。氮杂环丁烷卟啉、卟啉内酯和吗啉代卟啉是这类卟啉类化合物的代表性例子。这些卟啉衍生物由于其在光动力疗法中的潜在应用、作为多模态成像造影剂、近红外吸收染料、用于检测氧气、氰化物、次氯酸盐和pH值的光学传感器以及催化作用等，最近受到了越来越多的关注。
