Mehanna Emile, Hamik Anne, Josephson Richard A
Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Health System, Mailstop LKS 5038, 11100 Euclid Avenue, Cleveland, OH, 44106-5038, USA.
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Curr Atheroscler Rep. 2016 May;18(5):26. doi: 10.1007/s11883-016-0580-7.
Historically, the relationship between exercise and the cardiovascular system was viewed as unidirectional, with a disease resulting in exercise limitation and hazard. This article reviews and explores the bidirectional nature, delineating the effects, generally positive, on the cardiovascular system and atherosclerosis. Exercise augments eNOS, affects redox potential, and favorably affects mediators of atherosclerosis including lipids, glucose homeostasis, and inflammation. There are direct effects on the vasculature as well as indirect benefits related to exercise-induced changes in body composition and skeletal muscle. Application of aerobic exercise to specific populations is described, with the hope that this knowledge will move the science forward and improve individual patient outcome.
从历史上看，运动与心血管系统之间的关系被视为单向的，即疾病会导致运动受限和风险。本文回顾并探讨了这种双向关系，阐述了运动对心血管系统和动脉粥样硬化通常具有的积极影响。运动可增强内皮型一氧化氮合酶（eNOS），影响氧化还原电位，并对动脉粥样硬化的介质产生有利影响，包括脂质、葡萄糖稳态和炎症。运动对脉管系统有直接影响，同时也与运动引起的身体成分和骨骼肌变化相关的间接益处有关。文中描述了有氧运动在特定人群中的应用，希望这些知识能推动该领域科学的发展并改善个体患者的治疗效果。
