阐明复制起始中依赖DDK的步骤。
Elucidating the DDK-dependent step in replication initiation.
作者信息
Araki Hiroyuki
机构信息
National Institute of Genetics, Mishima, Japan.
出版信息
EMBO J. 2016 May 2;35(9):907-8. doi: 10.15252/embj.201694227. Epub 2016 Mar 22.
Abstract
By phosphorylating specific replication factors, cell cycle kinases ensure that eukaryotic DNA replication is initiated once and only once per mitotic cell division. New work in now reveals how DDK‐mediated phosphorylation of Mcm2‐7 helicase subunits is read out by Sld3, which provides further integration with CDK phosphorylation.
摘要
通过磷酸化特定的复制因子，细胞周期激酶确保真核生物DNA复制在每个有丝分裂细胞分裂中仅起始一次。目前的新研究揭示了Sld3如何读取由DDK介导的Mcm2 - 7解旋酶亚基的磷酸化作用，这进一步实现了与CDK磷酸化的整合。
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