比较舒芬太尼与咪达唑仑预防依托咪酯后肌阵挛性运动疗效的研究。
Comparative study evaluating efficacy of sufentanil versus midazolam in preventing myoclonic movements following etomidate.
作者信息
Alipour Mohammad, Tabari Masoumeh, Azad Azadeh Mokhtari
机构信息
Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
J Anaesthesiol Clin Pharmacol. 2016 Jan-Mar;32(1):29-32. doi: 10.4103/0970-9185.173382.
Abstract
BACKGROUND AND AIMS
Myoclonus is a major side-effect following etomidate injection requiring use of medical intervention.
MATERIAL AND METHODS
In this double-blinded clinical trial, 50 consecutive patients, randomly received sufentanil 0.2 μg/kg or midazolam 0.015 mg/kg, 90 s before induction of anesthesia with etomidate (0.3 mg/kg). Then, the patients were monitored for any myoclonic movements during anesthesia.
RESULTS
The incidence of myoclonus was 28% in the sufentanil group and 84% in the midazolam group. The frequency and intensity of myoclonus were significantly higher in the midazolam group, compared to the sufentanil group (P < 0.001). Myoclonus duration in the sufentanil and midazolam groups were 5.8 ± 13.2 and 69 ± 47.8 s, respectively (P < 0.0010).
CONCLUSION
The frequency, intensity and duration of myoclonus in the midazolam group, were significantly more prevalent than the sufentanil group.
摘要
背景与目的
肌阵挛是依托咪酯注射后的主要副作用，需要进行医学干预。
材料与方法
在这项双盲临床试验中，50例连续患者在依托咪酯（0.3mg/kg）麻醉诱导前90秒随机接受舒芬太尼0.2μg/kg或咪达唑仑0.015mg/kg。然后，在麻醉期间对患者进行任何肌阵挛运动的监测。
结果
舒芬太尼组肌阵挛发生率为28%，咪达唑仑组为84%。与舒芬太尼组相比，咪达唑仑组肌阵挛的频率和强度显著更高（P<0.001）。舒芬太尼组和咪达唑仑组的肌阵挛持续时间分别为5.8±13.2秒和69±47.8秒（P<0.0010）。
结论
咪达唑仑组肌阵挛的频率、强度和持续时间明显比舒芬太尼组更普遍。
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