Dawoud Mohamed Z, Nasr Mohamed
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11790, Egypt.
Acta Pharm Sin B. 2016 Mar;6(2):163-9. doi: 10.1016/j.apsb.2016.01.004. Epub 2016 Jan 25.
Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transfer of a model drug was measured. The detection of the model drug transferred from monoolein cubic particles and trimyristin solid lipid nanoparticles into emulsion droplets was performed using a flow cytometric technique. A higher rate and amount of porphyrin transfer from the solid lipid nanoparticles compared to the monoolein cubic particles was observed. This difference might be attributed to the formation of a highly ordered particle which leads to the expulsion of drug to the surface of the crystalline particle. Furthermore, the sponge-like structure of the monoolein cubic particles decreases the rate and amount of drug transferred. In conclusion, the flow cytometric technique is a suitable technique to study drug transfer from these carriers to large lipophilic acceptors. Monoolein cubic particles with their unique structure can be used successfully as a drug carrier with slow drug release compared with trimyristin nanoparticles.
诸如固体脂质纳米粒和液晶纳米粒之类的胶体脂质颗粒作为药物载体具有很大的潜力，特别是对于旨在静脉给药的亲脂性药物而言。为了评估这些纳米粒的药物释放情况并确定其给药后的行为，乳液滴被用作亲脂性隔室，用于测量模型药物向其中的转移。使用流式细胞术检测从单油酸甘油酯立方颗粒和肉豆蔻酸甘油三酯固体脂质纳米粒转移到乳液滴中的模型药物。观察到与单油酸甘油酯立方颗粒相比，从固体脂质纳米粒转移的卟啉速率和量更高。这种差异可能归因于形成了高度有序的颗粒，这导致药物被排出到晶体颗粒的表面。此外，单油酸甘油酯立方颗粒的海绵状结构降低了药物转移的速率和量。总之，流式细胞术是研究药物从这些载体向大型亲脂性受体转移的合适技术。与肉豆蔻酸甘油三酯纳米粒相比，具有独特结构的单油酸甘油酯立方颗粒可以成功用作具有缓慢药物释放的药物载体。
