那他珠单抗治疗患者的急性隐球菌免疫重建炎症综合征。
Acute Cryptococcal Immune Reconstitution Inflammatory Syndrome in a Patient on Natalizumab.
机构信息
Department of Medicine, Division of Infectious Diseases.
Departments of Neurology.
出版信息
Open Forum Infect Dis. 2016 Feb 17;3(1):ofw038. doi: 10.1093/ofid/ofw038. eCollection 2016 Jan.
Abstract
Presented is the first case of acute immune reconstitution inflammatory syndrome (IRIS)-associated cryptococcal meningoencephalitis in a patient on natalizumab for multiple sclerosis. The patient developed acute cerebral edema after initiation of amphotericin B. We propose several mechanisms that explain the acuity of IRIS in this specific patient population and suggest possible therapies.
摘要
现报道一例多发性硬化症患者接受那他珠单抗治疗后出现急性免疫重建炎症综合征（IRIS）相关隐球菌性脑膜脑炎。该患者在开始使用两性霉素 B 后出现急性脑水肿。我们提出了几种机制来解释该特定患者人群中 IRIS 的严重性，并提出了可能的治疗方法。
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