Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Front Immunol. 2018 Aug 14;9:1864. doi: 10.3389/fimmu.2018.01864. eCollection 2018.
Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity. Regulation is multifactorial and includes a number of epigenetic pathways which can involve modification of DNA-binding histones to induce autophagy-related mRNA synthesis or microRNA and decapping-associated mRNA degradation which results in autophagy suppression. Appreciation of epigenetic-based pathways involved in autophagy and autoimmunity may facilitate application of a burgeoning group of epigenetic pharmaceuticals to these important diseases.
自身免疫性疾病是全球范围内导致身体虚弱和死亡的一个重要原因，因此需要具有成本效益的治疗方法。自噬是一种细胞途径，可促进参与病原体控制和自身免疫的免疫调节。调控是多因素的，包括许多表观遗传途径，这些途径可以包括修饰 DNA 结合组蛋白以诱导与自噬相关的 mRNA 合成或 microRNA 和脱帽相关的 mRNA 降解，从而抑制自噬。了解参与自噬和自身免疫的表观遗传途径，可能有助于将一组新兴的表观遗传药物应用于这些重要疾病。
