Golabek Tomasz, Bukowczan Jakub, Szopinski Tomasz, Chlosta Piotr, Lipczynski Waclaw, Dobruch Jakub, Borowka Andrzej
Department of Urology, Collegium Medicum of the Jagiellonian University, Cracow, Poland.
Department of Diabetes and Endocrinology, James Cook University Hospital, Middlesbrough, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, United Kingdom.
Ann Agric Environ Med. 2016;23(1):37-43. doi: 10.5604/12321966.1196850.
There have been many studies published recently on obesity and the risk of renal cancer; however, the epidemiological evidence for such an association has not been consistent. Therefore, a systematic review was conducted of the prospective cohort studies to assess the association between obesity and the risk of renal cancer incidence and death.
A search was conducted of the PubMed database and references to published studies from inception until May 2013. Guidelines for Assessing Quality in Prognostic Studies on the Basis of Framework for Potential Biases were followed for quality assessment of studies included in the systematic review.
Twenty eligible studies were identified and included in the systematic review. Among the 20 selected studies, overall study quality was high. Although the evidence from the prospective cohort studies, linking obesity with renal cancer incidence, has not been entirely consistent, there is a convincing body of data for a positive relationship. Moreover, cumulative data is compelling for a strong positive association between obesity and fatal renal cancer.
There is a relatively consistent amount of evidence that obesity increases the risk of renal cancer and fatal renal cancer. Further research is needed as better understanding of mechanisms by which obesity may influence renal cancer development and progression will aid the fostering of strategies for prevention and treatment of one of the most lethal human malignancies.
最近发表了许多关于肥胖与肾癌风险的研究；然而，这种关联的流行病学证据并不一致。因此，对前瞻性队列研究进行了系统综述，以评估肥胖与肾癌发病及死亡风险之间的关联。
检索了PubMed数据库以及从研究起始至2013年5月已发表研究的参考文献。依据潜在偏倚框架下的预后研究质量评估指南，对纳入系统综述的研究进行质量评估。
确定了20项符合条件的研究并纳入系统综述。在这20项入选研究中，总体研究质量较高。尽管前瞻性队列研究中关于肥胖与肾癌发病之间的证据并不完全一致，但有令人信服的数据表明存在正相关关系。此外，累积数据有力地证明了肥胖与致命性肾癌之间存在强正相关。
有相对一致的证据表明肥胖会增加肾癌和致命性肾癌的风险。需要进一步开展研究，因为更好地理解肥胖可能影响肾癌发生和进展的机制，将有助于制定针对这种最致命人类恶性肿瘤之一的预防和治疗策略。
