《癌症基因组图谱（TCGA）实用指南》

A Practical Guide to The Cancer Genome Atlas (TCGA).

作者信息

Wang Zhining, Jensen Mark A, Zenklusen Jean Claude

机构信息

Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD, USA.

Research Administration Directorate, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, 8560 Progress Drive, Frederick, 21701, MD, USA.

出版信息

Methods Mol Biol. 2016;1418:111-41. doi: 10.1007/978-1-4939-3578-9_6.

DOI:10.1007/978-1-4939-3578-9_6

PMID:27008012

Abstract

The Cancer Genome Atlas (TCGA) is one of the most ambitious and successful cancer genomics programs to date. The TCGA program has generated, analyzed, and made available genomic sequence, expression, methylation, and copy number variation data on over 11,000 individuals who represent over 30 different types of cancer. This chapter provides a brief overview of the TCGA program and detailed instructions and tips for investigators on how to find, access, and download this data.

摘要

癌症基因组图谱（TCGA）是迄今为止最具雄心且最为成功的癌症基因组学项目之一。TCGA项目已生成、分析并公开了超过11000名个体的基因组序列、表达、甲基化和拷贝数变异数据，这些个体代表了30多种不同类型的癌症。本章简要概述了TCGA项目，并为研究人员提供了关于如何查找、获取和下载这些数据的详细说明与提示。