Ensembl基因组浏览器：获取真核生物基因组数据的策略。

The Ensembl Genome Browser: Strategies for Accessing Eukaryotic Genome Data.

作者信息

Newman Victoria, Moore Benjamin, Sparrow Helen, Perry Emily

机构信息

European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.

出版信息

Methods Mol Biol. 2018;1757:115-139. doi: 10.1007/978-1-4939-7737-6_6.

DOI:10.1007/978-1-4939-7737-6_6

PMID:29761458

Abstract

The Ensembl Genome Browser provides a wealth of freely available genomic data that can be accessed for many purposes by genetics, genomics, and molecular biology researchers. Herein we present two protocols for exploring different aspects of these data: a phenotype and its associated variants and genes, and a promoter and the epigenetic marks and protein-binding activity associated with it. These workflows illustrate a subset of the data types available through the Ensembl Browser, and can be considered a springboard for further exploration.

摘要

Ensembl基因组浏览器提供了大量免费的基因组数据，遗传学、基因组学和分子生物学研究人员可出于多种目的访问这些数据。在此，我们展示了两种探索这些数据不同方面的方案：一种表型及其相关的变异和基因，以及一个启动子及其相关的表观遗传标记和蛋白质结合活性。这些工作流程说明了通过Ensembl浏览器可获得的数据类型的一个子集，可被视为进一步探索的跳板。