Ross N M, Charles C H, Dills S S
J Clin Dent. 1989 Spring;1(4):92-5.
Chemotherapeutic mouthrinses are useful adjuncts to normal oral hygiene and regular professional care for patients whose mechanical plaque removal is less than optimal. Recognizing this, the American Dental Association Council on Dental Therapeutics published guidelines for evaluating the safety and efficacy of products for the control of gingivitis. Four 6-month or longer controlled clinical trials have shown Listerine to be significantly effective in helping prevent the development of both supragingival plaque and gingivitis. Two microbiology studies have demonstrated that no resistant microorganisms, opportunistic microorganisms, or presumptive oral pathogens emerge as a result of long-term, daily Listerine use. Listerine is the first nonprescription mouthrinse to receive the Council on Dental Therapeutics Seal of Acceptance as safe and effective in helping to prevent and reduce supragingival plaque accumulation and gingivitis when used in a conscientiously applied program of oral hygiene and regular professional care.
对于机械性菌斑清除效果欠佳的患者，化疗性漱口水是常规口腔卫生护理及定期专业护理的有益辅助手段。认识到这一点后，美国牙科协会牙科治疗委员会发布了评估控制牙龈炎产品安全性和有效性的指南。四项为期6个月或更长时间的对照临床试验表明，李施德林漱口水在帮助预防龈上菌斑和牙龈炎的发展方面具有显著效果。两项微生物学研究表明，长期每日使用李施德林漱口水不会产生耐药微生物、机会性微生物或推定的口腔病原体。李施德林漱口水是首款获得牙科治疗委员会认可印章的非处方漱口水，当与认真执行的口腔卫生护理及定期专业护理方案一起使用时，有助于预防和减少龈上菌斑积聚及牙龈炎，且安全有效。
