Seitz Johanna, Zuo Jessica X, Lyall Amanda E, Makris Nikos, Kikinis Zora, Bouix Sylvain, Pasternak Ofer, Fredman Eli, Duskin Jonathan, Goldstein Jill M, Petryshen Tracey L, Mesholam-Gately Raquelle I, Wojcik Joanne, McCarley Robert W, Seidman Larry J, Shenton Martha E, Koerte Inga K, Kubicki Marek
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany;
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA;
Schizophr Bull. 2016 May;42(3):762-71. doi: 10.1093/schbul/sbv171. Epub 2016 Mar 23.
Tractography is the most anatomically accurate method for delineating white matter tracts in the brain, yet few studies have examined multiple tracts using tractography in patients with schizophrenia (SCZ). We analyze 5 white matter connections important in the pathophysiology of SCZ: uncinate fasciculus, cingulum bundle (CB), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus, and arcuate fasciculus (AF). Additionally, we investigate the relationship between diffusion tensor imaging (DTI) markers and neuropsychological measures.
High-resolution DTI data were acquired on a 3 Tesla scanner in 30 patients with early-course SCZ and 30 healthy controls (HC) from the Boston Center for Intervention Development and Applied Research study. After manually guided tracts delineation, fractional anisotropy (FA), trace, radial diffusivity (RD), and axial diffusivity (AD) were calculated and averaged along each tract. The association of DTI measures with the Scales for the Assessment of Negative and Positive Symptoms and neuropsychological measures was evaluated.
Compared to HC, patients exhibited reduced FA and increased trace and RD in the right AF, CB, and ILF. A discriminant analysis showed the possible use of FA of these tracts for better future group membership classifications. FA and RD of the right ILF and AF were associated with positive symptoms while FA and RD of the right CB were associated with memory performance and processing speed.
We observed white matter alterations in the right CB, ILF, and AF, possibly caused by myelin disruptions. The structural abnormalities interact with cognitive performance, and are linked to clinical symptoms.
纤维束成像术是描绘大脑白质纤维束最具解剖学准确性的方法，但很少有研究使用纤维束成像术对精神分裂症（SCZ）患者的多条纤维束进行检查。我们分析了在SCZ病理生理学中重要的5条白质连接：钩束、扣带束（CB）、下纵束（ILF）、上纵束和弓状束（AF）。此外，我们还研究了扩散张量成像（DTI）标记物与神经心理学测量之间的关系。
从波士顿干预发展与应用研究中心的研究中，在30例早期病程SCZ患者和30名健康对照者（HC）中，使用3特斯拉扫描仪获取高分辨率DTI数据。在手动引导下描绘纤维束后，计算各纤维束的分数各向异性（FA）、迹值、径向扩散率（RD）和轴向扩散率（AD），并求平均值。评估DTI测量值与阴性和阳性症状评定量表以及神经心理学测量之间的关联。
与HC相比，患者右侧AF、CB和ILF的FA降低，迹值和RD升高。判别分析表明，这些纤维束的FA可能有助于更好地进行未来的组间分类。右侧ILF和AF的FA和RD与阳性症状相关，而右侧CB的FA和RD与记忆表现和处理速度相关。
我们观察到右侧CB、ILF和AF存在白质改变，可能是由髓鞘破坏引起的。结构异常与认知表现相互作用，并与临床症状相关。
