Ryuno Hirochika, Kamide Kei, Gondo Yasuyuki, Nakama Chikako, Oguro Ryosuke, Kabayama Mai, Kawai Tatsuo, Kusunoki Hiroshi, Yokoyama Serina, Imaizumi Yuki, Takeya Miyuki, Yamamoto Hiroko, Takeda Masao, Takami Yoichi, Itoh Norihisa, Yamamoto Koichi, Takeya Yasushi, Sugimoto Ken, Nakagawa Takeshi, Ikebe Kazunori, Inagaki Hiroki, Masui Yukie, Ishizaki Tatsuro, Takayama Michiyo, Arai Yasumichi, Takahashi Ryutaro, Rakugi Hiromi
Division of Health Science, Osaka University, Graduate School of Medicine, Osaka, Japan.
Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Hypertens Res. 2016 Jul;39(7):557-63. doi: 10.1038/hr.2016.25. Epub 2016 Mar 24.
High blood pressure in middle age (up to 64 years) has been proposed as a predictive indicator of dementia. However, the association between hypertension and the cognitive functioning is controversial in older age groups. The aim of this study was to investigate this association in 70-80-year-old participants in the Japanese study of Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC). Participants aged 70 (±1) and 80 (±1) years (n=1000 and 973, respectively) were randomly recruited from the general population in Japan. Cognitive functioning was measured by the Montreal Cognitive Assessment. Blood pressure and other medical and social variables were analyzed by multiple regression analyses. High systolic blood pressure (SBP) was significantly correlated with a reduced cognitive functioning only in participants aged 70 years. Additionally, this correlation became more marked in participants with uncontrolled blood pressure at age 70 years. In contrast, SBP was not significantly correlated with the cognitive functioning at age 80 years. Nutritional status indicators such as serum albumin and frequency of going outdoors were significantly associated with cognitive functioning at age 80 years. Our findings indicate that high SBP has a significant role in cognitive functioning at age 70 years; however, blood pressure is less important as a risk factor for cognitive decline at age 80 years.
中年（64岁及以下）高血压已被认为是痴呆症的预测指标。然而，在老年人群中，高血压与认知功能之间的关联存在争议。本研究的目的是在日本七旬老人、八旬老人、九旬老人和百岁老人调查研究（SONIC）中，对70至80岁的参与者进行此项关联研究。从日本普通人群中随机招募了年龄在70（±1）岁和80（±1）岁的参与者（分别为1000人和973人）。通过蒙特利尔认知评估来测量认知功能。通过多元回归分析对血压及其他医学和社会变量进行分析。仅在70岁的参与者中，高收缩压（SBP）与认知功能下降显著相关。此外，这种相关性在70岁时血压未得到控制的参与者中更为明显。相比之下，80岁时SBP与认知功能无显著相关性。营养状况指标，如血清白蛋白和户外活动频率，在80岁时与认知功能显著相关。我们的研究结果表明，高SBP在70岁时对认知功能有显著影响；然而，在80岁时，血压作为认知衰退的风险因素则不那么重要。
