Blanc A P, Gastuat J A, Dalivoust P, Carcassonne Y
Nouv Presse Med. 1977;6(28):2503-9.
In the first 3 cases, the initial disorder was a renal problem (glomerulonephritis, renal homograft). The development of secondary neoplasms appeared to be related to long term immunosuppressive therapy. By contrast, in the fourth case the primary disease was already malignant in nature (breast neoplasm) and treatment was mixed (radiotherapy and chemotherapy). In the light of these cases, the risks of treatment using immunosuppressive chemotherapy should not be neglected.
在前3例中，最初的病症是肾脏问题（肾小球肾炎、同种异体肾移植）。继发性肿瘤的发生似乎与长期免疫抑制治疗有关。相比之下，在第4例中，原发性疾病本质上已是恶性（乳腺肿瘤），治疗方式为综合治疗（放疗和化疗）。鉴于这些病例，免疫抑制化疗的治疗风险不容忽视。
