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使用自掺杂聚苯胺纳米颗粒对癌细胞进行光热消融。

Photothermal ablation of cancer cells using self-doped polyaniline nanoparticles.

作者信息

Hong Yoochan, Cho Wonseok, Kim Jeonghun, Hwng Seungyeon, Lee Eugene, Heo Dan, Ku Minhee, Suh Jin-Suck, Yang Jaemoon, Kim Jung Hyun

出版信息

Nanotechnology. 2016 May 6;27(18):185104. doi: 10.1088/0957-4484/27/18/185104.

Abstract

Water-stable confined self-doping polyaniline nanocomplexes are successfully fabricated by nano-assembly using lauric acid both as a stabilizer and as a localized dopant. In particular, the colloidal stability of the polyaniline nanocomplexes in neutral pH and the photothermal potential by near-infrared light irradiation are characterized. We demonstrate that confined self-doping polyaniline nanocomplexes as a photothermal nanoagent are preserved in the doped state even at a neutral pH. Finally, confined self-doping polyaniline nanocomplexes aided by lauric acid are successfully applied for the photothermal ablation of cancer cells.

摘要

通过纳米组装,使用月桂酸作为稳定剂和局部掺杂剂,成功制备了水稳定的受限自掺杂聚苯胺纳米复合物。特别地,对聚苯胺纳米复合物在中性pH下的胶体稳定性以及近红外光照射下的光热潜力进行了表征。我们证明,作为光热纳米剂的受限自掺杂聚苯胺纳米复合物即使在中性pH下也能保持在掺杂状态。最后,由月桂酸辅助的受限自掺杂聚苯胺纳米复合物成功应用于癌细胞的光热消融。

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