Traoré Karim, Arama Charles, Médebielle Maurice, Doumbo Ogobara, Picot Stéphane
Malaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali - Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie, de Biologie Moléculaire et Supramoléculaire ICBMS-UMR5246, CNRS-INSA-CPE, Malaria Research Unit, - 43 boulevard du 11 novembre 1918, 69622 Lyon, France.
Malaria Research and Training Center MRTC-DEAP-FMPOS-UMI 3189, Université des Sciences, des Techniques et des Technologies de Bamako, BP 1805, Bamako, Mali.
Parasite. 2016;23:15. doi: 10.1051/parasite/2016015. Epub 2016 Mar 24.
There are growing data supporting the differences in susceptibility to malaria described between sympatric populations with different lifestyles. Evidence has also been growing for some time that nutritional status and the host's metabolism are part of the complex mechanisms underlying these differences. The role of dietary advanced glycation end-products (AGEs) in the modulation of immune responses (innate and adaptive responses) and chronic oxidative stress has been established. But less is known about AGE implication in naturally acquired immunity and susceptibility to malaria. Since inflammatory immune responses and oxidative events have been demonstrated as the hallmark of malaria infection, it seems crucial to investigate the role of AGE in susceptibility or resistance to malaria. This review provides new insight into the relationship between nutrition, metabolic disorders, and infections, and how this may influence the mechanisms of susceptibility or resistance to malaria in endemic areas.
越来越多的数据支持了不同生活方式的同域种群之间所描述的对疟疾易感性的差异。一段时间以来，也有越来越多的证据表明，营养状况和宿主的新陈代谢是这些差异背后复杂机制的一部分。膳食晚期糖基化终产物（AGEs）在调节免疫反应（固有和适应性反应）以及慢性氧化应激中的作用已经得到证实。但关于AGEs在自然获得性免疫和疟疾易感性中的影响，人们了解得较少。由于炎症免疫反应和氧化事件已被证明是疟疾感染的标志，因此研究AGEs在疟疾易感性或抗性中的作用似乎至关重要。本综述为营养、代谢紊乱和感染之间的关系提供了新的见解，以及这如何可能影响流行地区疟疾易感性或抗性的机制。
