Arama Charles, Maiga Bakary, Dolo Amagana, Kouriba Bourèma, Traoré Boubacar, Crompton Peter D, Pierce Susan K, Troye-Blomberg Marita, Miller Louis H, Doumbo Ogobara K
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, FMOS-FAPH, ICER Mali-NIAID, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, FMOS-FAPH, ICER Mali-NIAID, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.
Acta Trop. 2015 Jun;146:152-6. doi: 10.1016/j.actatropica.2015.03.023. Epub 2015 Mar 27.
There are many fundamental aspects of the immunobiology of Plasmodium falciparum infections that are not fully understood, therefore limiting our comprehension of how people become immune to malaria and why some ethnic groups living in malaria endemic areas are less susceptible than others. The complexity of parasite-host interactions and the genetic diversity of the parasites as well as the human host complicate our strategy to address this issue. In this mini-review we discuss and summarize what we have learned about African ethnic differences in susceptibility to malaria from immuno-epidemiological studies. Additionally, we suggest research topics that might be of great value for dissecting the mechanisms of protection by providing new insights into molecular interactions between the parasite and the host.
恶性疟原虫感染免疫生物学的许多基本方面尚未完全明了，因此限制了我们对人们如何获得疟疾免疫力以及为何生活在疟疾流行地区的一些族群比其他族群更不易感的理解。寄生虫与宿主相互作用的复杂性、寄生虫以及人类宿主的遗传多样性使我们解决这一问题的策略变得复杂。在这篇小型综述中，我们讨论并总结了从免疫流行病学研究中了解到的关于非洲族群对疟疾易感性差异的情况。此外，我们提出了一些研究课题，这些课题可能通过提供关于寄生虫与宿主之间分子相互作用的新见解，对剖析保护机制具有重要价值。
