Dini Valentina, Martini Patrizia, Bellini Mauro, Bagnoni Giovanni, Marsili Franco, Lancia Ugo
Department of Dermatology, University of Pisa, Pisa, Italy.
Unit of Dermatology, Hospital of Lucca, Lucca, Italy.
G Ital Dermatol Venereol. 2017 Feb;152(1):24-27. doi: 10.23736/S0392-0488.16.05232-9. Epub 2016 Mar 24.
Psoriasis arthritis will develop during cutaneous psoriasis in a significant percentage. The aim of this study was to improve assistance to patients and to provide the most individualized care possible.
Patients: all consecutive subjects with psoriasis accessing the outpatients facilities of five dermatologic centers of excellence in the Tuscany region of Italy between December 2014 and February 2015. All subjects were screened for the presence of a previous diagnosis of arthritis and symptoms affecting the articular system, using some questions chosen and shared by dermatologists in charge of the centers.
In the chosen three months period, 134 patients affected with psoriasis had been observed, 32 (24%) of which answered "yes" to the question "Have you ever been diagnosed with arthritis?". There have been differences in the characteristics of patients in the two groups, with and without arthritis. In particular, in the arthritis patients a statistically significant higher mean age, more ungueal psoriasis, less body surface cutaneous psoriasis extension, and a statistically significant higher percentage of patients treated with biological drugs (57% vs. 24.5%) have been observed.
The results were consistent with the scientific literature in the field. The experience seems to confirm the opportunity of screening programs on arthropathy in cutaneous psoriasis patients. About a quarter of psoriasis patients had relevant arthropathic features, and more than half of these required challenging therapies like biologics.
相当比例的皮肤银屑病患者会发展为银屑病关节炎。本研究的目的是改善对患者的帮助并提供尽可能个性化的护理。
患者:2014年12月至2015年2月期间,意大利托斯卡纳地区五个卓越皮肤科中心门诊设施接待的所有连续性银屑病患者。使用各中心负责皮肤科医生共同选定的一些问题,对所有受试者进行筛查,以确定其既往是否有关节炎诊断以及是否存在影响关节系统的症状。
在选定的三个月期间,共观察到134例银屑病患者,其中32例(24%)对“你是否曾被诊断患有关节炎?”这一问题回答“是”。患有关节炎和未患关节炎的两组患者在特征上存在差异。特别是,关节炎患者的平均年龄在统计学上显著更高,甲银屑病更多,体表皮肤银屑病累及范围更小,且接受生物药物治疗的患者百分比在统计学上显著更高(57%对24.5%)。
结果与该领域的科学文献一致。该经验似乎证实了对皮肤银屑病患者进行关节病筛查项目的必要性。约四分之一的银屑病患者具有相关关节病特征,其中一半以上需要生物制剂等具有挑战性的治疗。