Gur D, Yonas H, Good W F
Department of Diagnostic Radiology, University of Pittsburgh, PA 15261.
Cerebrovasc Brain Metab Rev. 1989 Spring;1(1):68-86.
A noninvasive technique for measuring local cerebral blood flow (CBF) by xenon-enhanced x-ray transmission computed tomography (CT) was developed and reported on extensively in recent years. In this method, nonradioactive xenon gas in inhaled, and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential computed tomography. Time-dependent xenon concentration within various tissue segments in the brain is used to derive both the local partition coefficient (lambda) and CBF in each tissue volume (voxel) of the CT image. A comprehensive assessment of this method reveals that although it provides functional mapping of blood flow with excellent anatomic specificity and has several other significant advantages, there are distinct and important limitations. The assumptions underlying this methodology are examined and the advantages as well as the problems associated with applications of this technique are reviewed. Laboratory and clinical observations that have been made using this technique in recent years are summarized, and potential improvements as well as possible future directions are discussed.
近年来，一种通过氙增强X射线透射计算机断层扫描（CT）测量局部脑血流量（CBF）的非侵入性技术得到了开发，并被广泛报道。在这种方法中，吸入非放射性氙气，并通过连续计算机断层扫描测量吸入产生的射线照相增强的时间变化。大脑中各个组织段内随时间变化的氙浓度用于推导CT图像每个组织体积（体素）中的局部分配系数（λ）和CBF。对该方法的全面评估表明，尽管它以出色的解剖特异性提供血流功能图谱并具有其他几个显著优点，但也存在明显且重要的局限性。研究了该方法的基本假设，并综述了该技术应用的优点和相关问题。总结了近年来使用该技术进行的实验室和临床观察，并讨论了潜在的改进以及可能的未来方向。
