Gur D, Yonas H, Wolfson S K, Wozney P, Colsher J G, Good W F, Good B C, Herbert D L, Cook E E
J Comput Assist Tomogr. 1984 Dec;8(6):1124-7. doi: 10.1097/00004728-198412000-00015.
A noninvasive technique for measuring blood flow by xenon-enhanced X-ray transmission CT has been developed and reported quite extensively in recent years. In this method nonradioactive xenon gas is inhaled, and the temporal changes in radiographic enhancement produced by the inhalation are measured by sequential CT. Time-dependent xenon concentration within various tissue segments is used to derive local blood flow maps. The method has been amply discussed in relation to assessment of local cerebral blood flow. Its application to other body organs is explored in this paper, in which results from six preliminary blood flow studies in the liver and kidneys of nonhuman primates are reported. Blood flow in renal cortex ranged from 150 to 280 ml/100 cc/min and hepatic tissue perfusion from 80 to 120 ml/100 cc/min. The advantages and limitations of the method in such applications are discussed.
近年来，一种通过氙增强X射线透射CT测量血流的非侵入性技术已被开发出来，并得到了广泛报道。在这种方法中，吸入非放射性氙气，并通过连续CT测量吸入产生的放射造影增强的时间变化。利用不同组织段内随时间变化的氙浓度来推导局部血流图。关于局部脑血流评估，该方法已得到充分讨论。本文探讨了其在其他身体器官中的应用，其中报告了对非人类灵长类动物肝脏和肾脏进行的六项初步血流研究的结果。肾皮质血流范围为150至280毫升/100立方厘米/分钟，肝组织灌注范围为80至120毫升/100立方厘米/分钟。讨论了该方法在这类应用中的优点和局限性。
