Sundaresan N, Suite N D
Doctors Hospital, Columbia University College of Physicians and Surgeons.
Oncology (Williston Park). 1989 Dec;3(12):15-22; discussion 23.
A major obstacle to the effective systemic therapy of intracranial malignancies and infections, the bloodbrain barrier was overcome by the development of the Ommaya reservoir in 1963. Initially used in treating cryptococcal meningitis, this closed system for continued access to the ventricular spaces has a variety of applications. They include treatment of cancer pain, chronic or recurrent CNS infection, prophylaxis of CNS involvement in acute lymphoblastic leukemia, and treatment of leptomeningeal malignancy. The authors outline the rationale, latest indications, surgical technique, and potential complications arising from the use of the Ommaya reservoir and other such subcutaneous reservoirs.
血脑屏障是颅内恶性肿瘤和感染有效全身治疗的主要障碍，1963年奥马亚贮液器的研制克服了这一障碍。该封闭系统最初用于治疗隐球菌性脑膜炎，可持续进入脑室系统，有多种应用。包括治疗癌痛、慢性或复发性中枢神经系统感染、预防中枢神经系统受累于急性淋巴细胞白血病以及治疗软脑膜恶性肿瘤。作者概述了使用奥马亚贮液器及其他此类皮下贮液器的基本原理、最新适应证、手术技术和潜在并发症。
