Horowitz M E
Pediatric Branch National Cancer Institute.
Oncology (Williston Park). 1989 Mar;3(3):101-6; discussion 106-9.
Ewing's sarcoma, second only to osteosarcoma as the most common malignant bone tumor of children and adolescents, can be cured in more than half of all cases. Combination chemotherapy and local irradiation is the most effective multimodality approach, with chemotherapy being initiated as soon as possible after diagnosis and work-up. The first Intergroup Ewing's Sarcoma Study, completed in 1978, demonstrated that adjuvant therapy with vincristine, dactinomycin was superior to VAC alone or VAC with pulmonary irradiation. The most recent treatment advance is the identification of a high level of activity of ifosfamide and etoposide in patients with recurrent disease. This combination will soon be tested in a collaborative group Phase III trial.
尤因肉瘤是儿童和青少年中仅次于骨肉瘤的第二常见恶性骨肿瘤，超过半数的病例可以治愈。联合化疗和局部放疗是最有效的多模式治疗方法，诊断和检查后应尽快开始化疗。1978年完成的首个尤因肉瘤协作组研究表明，长春新碱、放线菌素D辅助治疗优于单独使用VAC或VAC联合肺部放疗。最新的治疗进展是发现异环磷酰胺和依托泊苷对复发性疾病患者具有高度活性。这种联合方案很快将在协作组的III期试验中进行测试。
