非酒精性脂肪性肝病患者中非酒精性脂肪性肝病与炎症的关系
Relationship between non-alcoholic fatty liver disease and inflammation in patients with non-alcoholic fatty liver.
作者信息
Foroughi Mehdi, Maghsoudi Zahra, Khayyatzadeh Saeid, Ghiasvand Reza, Askari Gholamreza, Iraj Bijan
机构信息
Department of Community Nutrition, Metabolic Liver Diseases Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, Metabolic Liver Diseases Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Food Security Research Center and Community Nutrition, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2016 Feb 15;5:28. doi: 10.4103/2277-9175.176368. eCollection 2016.
BACKGROUND
Non-alcoholic fatty liver is the most chronic liver disease that eventually can become cirrhosis. One of the underlying assumptions for the fatty liver created by inflammation of the hepatocytes. We aimed to assess the association between non-alcoholic fatty liver disease (NAFLD) and sub-clinical inflammation.
MATERIALS AND METHODS
This is a cross-sectional study which was conducted on 55 patients over 30 years, with NAFLD. Fatty liver grade was assessed using liver ultrasound. Liver enzymes (alanine aminotransferase, aspartate aminotransferase), anthropometric characteristics and inflammatory marker C-reactive protein (CRP) were measured. Qualitative variables (sex and fatty liver grade) and quantitative variables such as were compared with independent t-test and Chi-square test. Relationship between fatty liver grade and inflammatory index was assessed with SPSS software (version 20; SPSS, Inc. Chicago, IL, USA).
RESULTS
Non-alcoholic fatty liver grades were associated with CRP level and this relationship remains in statistically significant level even after adjusting the effects of confounding variables such as age, sex and body mass index of participants (P = 0.016).
CONCLUSION
In this cross-sectional study, presentation of NAFLD showed a significant correlation with sub-clinical systemic inflammation and CRP level.
背景
非酒精性脂肪性肝病是最常见的慢性肝病，最终可能发展为肝硬化。肝细胞炎症是导致脂肪肝的潜在原因之一。我们旨在评估非酒精性脂肪性肝病（NAFLD）与亚临床炎症之间的关联。
材料与方法
这是一项横断面研究，对55例年龄超过30岁的NAFLD患者进行了研究。使用肝脏超声评估脂肪肝分级。测量了肝酶（丙氨酸氨基转移酶、天冬氨酸氨基转移酶）、人体测量学特征和炎症标志物C反应蛋白（CRP）。定性变量（性别和脂肪肝分级）和定量变量等采用独立t检验和卡方检验进行比较。使用SPSS软件（版本20；SPSS公司，美国伊利诺伊州芝加哥）评估脂肪肝分级与炎症指数之间的关系。
结果
非酒精性脂肪肝分级与CRP水平相关，即使在调整了参与者的年龄、性别和体重指数等混杂变量的影响后，这种关系仍具有统计学意义（P = 0.016）。
结论
在这项横断面研究中，NAFLD的表现与亚临床全身炎症和CRP水平显著相关。
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