Schachter H, Brockhausen I
Department of Biochemistry, University of Toronto, Ontario, Canada.
Symp Soc Exp Biol. 1989;43:1-26.
The hypothesis put forward in this review is that the branching patterns at the core of Ser(Thr)-GalNAc oligosaccharides (O-glycans) determine the types of glycan that are synthesized and their functions. Biosynthetic pathways are presented for the four types of O-glycan core and for some of the more common glycans that are built on these cores. The four core types discussed are: (1) Gal beta 1-3GalNAc-alpha-Ser(Thr)-R, (2) Gal beta 1-3(GlcNAc beta 1-6)GalNAc-alpha-Ser(Thr)-R, (3) GlcNAc beta 1-3GalNAc-alpha-Ser(Thr)-R, and (4) GlcNAc beta 1-3(GlcNAc beta 1-6)GalNAc-alpha-Ser(Thr)-R. General rules concerning the control of synthesis of these molecules are derived.
本综述提出的假设是，丝氨酸（苏氨酸）-N-乙酰半乳糖胺寡糖（O-聚糖）核心处的分支模式决定了所合成聚糖的类型及其功能。文中展示了四种O-聚糖核心以及基于这些核心构建的一些更常见聚糖的生物合成途径。所讨论的四种核心类型为：（1）Galβ1-3GalNAc-α-Ser（Thr）-R，（2）Galβ1-3（GlcNAcβ1-6）GalNAc-α-Ser（Thr）-R，（3）GlcNAcβ1-3GalNAc-α-Ser（Thr）-R，以及（4）GlcNAcβ1-3（GlcNAcβ1-6）GalNAc-α-Ser（Thr）-R。由此得出了关于这些分子合成控制的一般规则。
