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[在400兆赫核磁共振分析后正常C1酯酶抑制剂（C1-INH）聚糖链的一级结构]

[Primary structure of the glycan chains of normal C 1 esterase inhibitor (C 1-INH) after NMR analysis at 400 MHz].

作者信息

Strecker G, Ollier-Hartmann M P, van Halbeek H, Vliegenthart J F, Montreuil J, Hartmann L

出版信息

C R Acad Sci III. 1985;301(11):571-6.

PMID:3936597
Abstract

The primary structural analysis of O- and N-linked carbohydrate chains of the C-1-esterase inhibitor purified from normal serum was carried out by 400-MHz 1H-NMR spectroscopy. C-1-esterase inhibitor protein of a molecular weight of 116,000 daltons contains 24 O-glycans: NeuAc (alpha 2-3) Gal (beta 1-3) GalNAc, 4 N-glycans: NeuAc (alpha 2-6) Gal (beta 1-4) (GlcNAc (beta 1-2) Man (alpha 1-3) [NeuAc (alpha 2-6) Gal (beta 1-4) GlcNAc (beta 1-2) Man (alpha 1-6)] Man (beta 1-4) GlcNAc (beta 1-4) GlcNAc and 2 N-glycans: NeuAc (alpha 2-3) Gal (beta 1-4) GlcNAc (beta 1-2) Man (alpha 1-3) [NeuAc (alpha 2-3) Gal (beta 1-4) GlcNAc (beta 1-2) Man (alpha 1-6)] Man (beta 1-4) GlcNAc (beta 1-4) GlcNAc. 30% of the N-glycans are fucosylated.

摘要

采用400兆赫的1H-NMR光谱法对从正常血清中纯化的C-1酯酶抑制剂的O-连接和N-连接碳水化合物链进行了一级结构分析。分子量为116,000道尔顿的C-1酯酶抑制剂蛋白含有24个O-聚糖：NeuAc（α2-3）Gal（β1-3）GalNAc，4个N-聚糖：NeuAc（α2-6）Gal（β1-4）（GlcNAc（β1-2）Man（α1-3）[NeuAc（α2-6）Gal（β1-4）GlcNAc（β1-2）Man（α1-6）]Man（β1-4）GlcNAc（β1-4）GlcNAc以及2个N-聚糖：NeuAc（α2-3）Gal（β1-4）GlcNAc（β1-2）Man（α1-3）[NeuAc（α2-3）Gal（β1-4）GlcNAc（β1-2）Man（α1-6）]Man（β1-4）GlcNAc（β1-4）GlcNAc。30%的N-聚糖被岩藻糖基化。

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[Primary structure of the glycan chains of normal C 1 esterase inhibitor (C 1-INH) after NMR analysis at 400 MHz].[在400兆赫核磁共振分析后正常C1酯酶抑制剂（C1-INH）聚糖链的一级结构]
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