The role of PTEN as a cancer biomarker.
作者信息
McCabe Nuala, Kennedy Richard D, Prise Kevin M
机构信息
Center for Cancer Research & Cell Biology, Queens University Belfast, UK.
出版信息
Oncoscience. 2016 Mar 3;3(2):54-5. doi: 10.18632/oncoscience.296. eCollection 2016.
Abstract
摘要
相似文献
1
The role of PTEN as a cancer biomarker.PTEN作为一种癌症生物标志物的作用。
Oncoscience. 2016 Mar 3;3(2):54-5. doi: 10.18632/oncoscience.296. eCollection 2016.
2
PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?PTEN作为癌症的预后/预测生物标志物：一个未实现的承诺？
Cancers (Basel). 2019 Mar 28;11(4):435. doi: 10.3390/cancers11040435.
3
The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover.肿瘤抑制因子PTEN：一种肿瘤抑制候选蛋白在PTEN周转中的作用。
Biochem Soc Trans. 2004 Apr;32(Pt 2):343-7. doi: 10.1042/bst0320343.
4
Clinical implications of PTEN loss in prostate cancer.PTEN 缺失在前列腺癌中的临床意义。
Nat Rev Urol. 2018 Apr;15(4):222-234. doi: 10.1038/nrurol.2018.9. Epub 2018 Feb 20.
5
PDZ-containing 1 acts as a suppressor of pancreatic cancer by regulating PTEN phosphorylation.含PDZ结构域的蛋白1通过调节PTEN磷酸化发挥胰腺癌抑制因子的作用。
Oncotarget. 2017 Aug 24;8(42):72893-72909. doi: 10.18632/oncotarget.20552. eCollection 2017 Sep 22.
6
The PTEN tumour suppressor gene and malignant melanoma.PTEN肿瘤抑制基因与恶性黑色素瘤。
Melanoma Res. 1998 Aug;8(4):300-2. doi: 10.1097/00008390-199808000-00002.
7
The functions and regulation of the PTEN tumour suppressor: new modes and prospects.PTEN 肿瘤抑制因子的功能与调节：新模式与新前景。
Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562. doi: 10.1038/s41580-018-0015-0.
8
The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene in prostate cancer cells.致癌转录因子ERG抑制前列腺癌细胞中肿瘤抑制基因的转录。
Oncol Lett. 2017 Nov;14(5):5605-5610. doi: 10.3892/ol.2017.6841. Epub 2017 Aug 28.
9
PTEN expression is a strong predictor of survival in mesothelioma patients.PTEN表达是间皮瘤患者生存的有力预测指标。
Eur J Cardiothorac Surg. 2008 Mar;33(3):502-6. doi: 10.1016/j.ejcts.2007.09.045. Epub 2008 Jan 8.
10
Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas.排除PTEN肿瘤抑制基因在乳腺癌中起主要作用的可能性。
Br J Cancer. 1999 Feb;79(5-6):754-8. doi: 10.1038/sj.bjc.6690121.
引用本文的文献
1
miR-29a-3p compositely regulates the COL6A6/PTEN-PI3K/Akt/CUX1 feedback loop to participate in the proliferation and invasion of pituitary adenomas.微小RNA-29a-3p通过复合调节COL6A6/PTEN-磷脂酰肌醇-3-激酶/蛋白激酶B/CUX1反馈环参与垂体腺瘤的增殖和侵袭。
J Mol Histol. 2025 May 27;56(3):172. doi: 10.1007/s10735-025-10436-0.
2
Potential of phosphatase and tensin gene polymorphisms as salivary biomarkers in oral squamous cell carcinoma - A cross-sectional study.磷酸酶和张力蛋白基因多态性作为口腔鳞状细胞癌唾液生物标志物的潜力——一项横断面研究。
J Oral Maxillofac Pathol. 2024 Oct-Dec;28(4):596-601. doi: 10.4103/jomfp.jomfp_118_24. Epub 2024 Dec 31.
3
GNL3 and PA2G4 as Prognostic Biomarkers in Prostate Cancer.GNL3和PA2G4作为前列腺癌的预后生物标志物
Cancers (Basel). 2023 May 11;15(10):2723. doi: 10.3390/cancers15102723.
4
Glycyl-tRNA Synthetase (GARS) Expression Is Associated with Prostate Cancer Progression and Its Inhibition Decreases Migration, and Invasion In Vitro.甘氨酰-tRNA 合成酶（GARS）的表达与前列腺癌的进展相关，其抑制作用可降低体外迁移和侵袭。
Int J Mol Sci. 2023 Feb 21;24(5):4260. doi: 10.3390/ijms24054260.
5
Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies.非裔美国人中前列腺癌的种族差异与可行的治疗思路和新型免疫疗法。
Cancer Rep (Hoboken). 2021 Oct;4(5):e1340. doi: 10.1002/cnr2.1340. Epub 2021 Feb 17.
6
Expression and association of IL-21, FBXL20 and tumour suppressor gene PTEN in laryngeal cancer.白细胞介素-21、FBXL20与抑癌基因PTEN在喉癌中的表达及相关性
Saudi J Biol Sci. 2019 Dec;26(8):2048-2051. doi: 10.1016/j.sjbs.2019.08.013. Epub 2019 Aug 16.
7
Correlation between PTEN and P62 gene expression in rat colorectal cancer cell.大鼠结肠癌细胞中PTEN与P62基因表达的相关性
Saudi J Biol Sci. 2019 Dec;26(8):1986-1990. doi: 10.1016/j.sjbs.2019.08.006. Epub 2019 Aug 10.
8
Precise Immunodetection of PTEN Protein in Human Neoplasia.精确免疫检测人类肿瘤中的 PTEN 蛋白。
Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a036293. doi: 10.1101/cshperspect.a036293.
9
10
Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT.miR-106b通过PTEN-PI3K/AKT对垂体腺瘤侵袭性的影响
Med Sci Monit. 2017 Mar 13;23:1277-1285. doi: 10.12659/msm.900092.
本文引用的文献
1
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.转移性前列腺癌中的DNA修复缺陷与奥拉帕利
N Engl J Med. 2015 Oct 29;373(18):1697-708. doi: 10.1056/NEJMoa1506859.
2
PTEN regulates DNA replication progression and stalled fork recovery.PTEN调节DNA复制进程和停滞叉的恢复。
Nat Commun. 2015 Jul 9;6:7620. doi: 10.1038/ncomms8620.
3
Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.针对 ATM 抑制剂靶向 PTEN 缺陷肿瘤细胞的机制原理。
Cancer Res. 2015 Jun 1;75(11):2159-65. doi: 10.1158/0008-5472.CAN-14-3502. Epub 2015 Apr 13.
4
PTEN: Multiple Functions in Human Malignant Tumors.PTEN：人类恶性肿瘤中的多种功能。
Front Oncol. 2015 Feb 16;5:24. doi: 10.3389/fonc.2015.00024. eCollection 2015.
5
PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate.醋酸阿比特龙治疗去势抵抗性前列腺癌时PTEN蛋白缺失与临床结局
Eur Urol. 2015 Apr;67(4):795-802. doi: 10.1016/j.eururo.2014.10.027. Epub 2014 Nov 4.
6
Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.肿瘤抑制因子 BRCA1 与受损 DNA 修复中 PTEN 的联系。
Front Oncol. 2014 Nov 10;4:318. doi: 10.3389/fonc.2014.00318. eCollection 2014.
7
Lifetime cancer risks in individuals with germline PTEN mutations.携带种系 PTEN 突变个体的终生癌症风险。
Clin Cancer Res. 2012 Jan 15;18(2):400-7. doi: 10.1158/1078-0432.CCR-11-2283.
8
PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.PTEN、PIK3CA、p-AKT 和 p-p70S6K 状态：与曲妥珠单抗治疗 HER2 阳性转移性乳腺癌患者的反应和生存的相关性。
Am J Pathol. 2010 Oct;177(4):1647-56. doi: 10.2353/ajpath.2010.090885. Epub 2010 Sep 2.
9
Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study.
BMC Cancer. 2008 Aug 13;8:234. doi: 10.1186/1471-2407-8-234.
Zotero 插件