Mei Yong-Jun, Wang Peng, Chen Lin-Jie, Li Zhi-Jun
Department of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
Arch Med Res. 2016 Feb;47(2):111-7. doi: 10.1016/j.arcmed.2016.03.001. Epub 2016 Mar 22.
Leptin is an adipokine that has several effects on metabolism and immune system in patients with ankylosing spondylitis (AS). The present investigations of the relationship between plasma/serum leptin levels and AS are contradictory. To derive a more precise estimation on the plasma/serum leptin levels in AS patients and related factors, a meta-analysis was performed.
Published literature that compares plasma/serum leptin levels between AS group and control group from PubMed, Embase, Cochrane Library and other databases were searched. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standardized mean difference (SMD) with its 95% confidence interval (CI) was calculated by fixed-effects or random-effect model analyses. Statistical heterogeneity within studies was examined by the Q statistic.
A total of eight studies including 391 AS patients and 293 healthy controls were finally included in the meta-analysis. No significant differences in plasma/serum leptin levels was found between AS patients and healthy controls when all studies were pooled into the meta-analysis (pooled SMD = 0.384, 95% CI = -1.522 to 0.753). Meanwhile, subgroup analyses by gender also showed no significant differences in plasma/serum leptin levels between case group and controls.
There is no significant difference in plasma/serum leptin levels between AS patients and controls.
瘦素是一种脂肪因子，对强直性脊柱炎（AS）患者的代谢和免疫系统有多种影响。目前关于血浆/血清瘦素水平与AS之间关系的研究结果相互矛盾。为了更精确地评估AS患者的血浆/血清瘦素水平及相关因素，进行了一项荟萃分析。
检索了来自PubMed、Embase、Cochrane图书馆及其他数据库中比较AS组与对照组血浆/血清瘦素水平的已发表文献。采用纽卡斯尔-渥太华量表评估研究质量。通过固定效应或随机效应模型分析计算合并标准化均数差（SMD）及其95%置信区间（CI）。采用Q统计量检验研究间的统计学异质性。
最终共有八项研究纳入荟萃分析，包括391例AS患者和293例健康对照。当所有研究纳入荟萃分析时，AS患者与健康对照之间的血浆/血清瘦素水平无显著差异（合并SMD = 0.384，95% CI = -1.522至0.753）。同时，按性别进行的亚组分析也显示病例组与对照组之间的血浆/血清瘦素水平无显著差异。
AS患者与对照之间的血浆/血清瘦素水平无显著差异。
