人子痫前期胎盘组织中瞬时受体电位香草酸亚型1（TRPV-1）的表达
TPRV-1 expression in human preeclamptic placenta.
作者信息
Martínez Nora, Abán Cyntia E, Leguizamón Gustavo F, Damiano Alicia E, Farina Mariana G
机构信息
Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Laboratorio de Fisiopatología Placentaria, CEFYBO-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
出版信息
Placenta. 2016 Apr;40:25-8. doi: 10.1016/j.placenta.2016.02.008. Epub 2016 Feb 13.
Preeclampsia is a multisystem disorder unique to human pregnancy, characterized by abnormal placentation. Although its causes remain unclear, it is known that the expression of several transporters is altered. Transient receptor potential vanilloid 1 (TRPV-1) is a nonselective cation channel, present in human placenta. Here, we evaluated the expression of TRPV-1 in preeclamptic placentas. We observed a deregulation in TRPV-1 expression in these placentas which may explain the impaired Ca(2+) homeostasis found in preeclampsia.
子痫前期是一种人类妊娠特有的多系统疾病，其特征是胎盘形成异常。尽管其病因尚不清楚，但已知几种转运蛋白的表达发生了改变。瞬时受体电位香草酸受体1（TRPV-1）是一种存在于人类胎盘中的非选择性阳离子通道。在此，我们评估了TRPV-1在子痫前期胎盘组织中的表达。我们观察到这些胎盘组织中TRPV-1的表达失调，这可能解释了子痫前期中发现的钙（Ca2+）稳态受损的原因。
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