Melita P, Barbuscia M, Calbo L, Belnome N A, Palmeri R, Lazzara S, Lorenzini C
Istituto di Chirurgia Generale, Università degli Studi di Messina.
Chir Ital. 1989 Aug-Dec;41(4-6):167-79.
The Authors claim that the treatment of malignant melanosis of the skin is a problem of undiminished topical interest owing to its highly aggressive characteristics. Risk factors and pre-neoplastic lesions are reviewed, and the signs of malignant transformation are described along with the appropriate treatment. The Authors stress the importance, for therapeutic and prognostic purposes, of accurate clinical staging and macro- and microscopic study of the primary tumour. They also describe their own therapeutic approach, which involves the use of a CO2 laser for resecting the primary tumour. They present their patient population and conclude by observing that the progress achieved over the past decade is due both to earlier diagnosis and to improvements in the various therapeutic means available.
作者们声称,由于皮肤恶性黑素沉着具有高度侵袭性的特征,其治疗仍是一个备受关注的局部问题。文中回顾了危险因素和癌前病变,并描述了恶性转化的征象以及相应的治疗方法。作者们强调,为了治疗和预后目的,准确的临床分期以及对原发性肿瘤进行大体和显微镜研究非常重要。他们还描述了自己的治疗方法,即使用二氧化碳激光切除原发性肿瘤。他们展示了患者群体,并指出过去十年所取得的进展归功于早期诊断以及现有各种治疗手段的改进。