Lasisz B, Zdrojewicz Z, Dul W, Markiewicz A, Strychalski J
Pol Tyg Lek. 1989;44(30-31):724-5.
A case of a 32-year female patient with the systemic lupus erythematosus is presented. The patient was treated with prednisone in a daily dose of 40-60 mg. Due to the exacerbations of the symptoms and advanced renal disorders, the patient was given TFX together with corticotherapy. Thymus factor X is an extract of real thymus of immunorecorrective properties. It specifically acts on the lymphatic system, especially disordered mechanisms of both cellular and humoral immunity. Thymus factor X was given in the dose of 10 mg (one ampoule) i.m. for the three first months followed by one ampoule every three days for the next three months. The patient is given one ampoule of TFX once a week since the 6th months of therapy. Diminishment of the symptoms was observed. The patient is in remission since a one-year follow-up period. It was also possible to reduce the dose of prednisone to 15 mg a day. The patient is controlled every 3 months. Partial normalization of renal functioning and immunological mechanisms are seen. A decrease in antinuclear antibodies and immunoglobulins, normalization in complement components, an increase in T-cells percentage and conversion of the delayed skin reaction are noted. The authors conclude that TFX may be helpful in the treatment of the autoimmunological diseases, including the systemic lupus erythematosus.
本文介绍了一例32岁的系统性红斑狼疮女性患者。该患者接受泼尼松治疗，每日剂量为40 - 60毫克。由于症状加重和严重的肾脏疾病，患者在接受皮质激素治疗的同时给予了胸腺因子X（TFX）。胸腺因子X是具有免疫纠正特性的真正胸腺提取物。它特异性作用于淋巴系统，尤其是细胞免疫和体液免疫的紊乱机制。最初三个月，胸腺因子X的给药剂量为10毫克（一支），肌肉注射，之后的三个月每三天注射一支。自治疗的第6个月起，患者每周注射一支TFX。观察到症状有所减轻。经过一年的随访期，患者处于缓解状态。同时也有可能将泼尼松的剂量减至每日15毫克。每3个月对患者进行一次检查。可见肾功能和免疫机制部分恢复正常。抗核抗体和免疫球蛋白减少，补体成分恢复正常，T细胞百分比增加，迟发性皮肤反应转为阳性。作者得出结论，TFX可能有助于治疗自身免疫性疾病，包括系统性红斑狼疮。
