介孔硅纳米颗粒具有有机桥联硅倍半氧烷骨架，可用作生物成像和治疗剂递送的创新平台。
Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery.
机构信息
Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, China; School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia.
Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Biomaterials. 2016 Jun;91:90-127. doi: 10.1016/j.biomaterials.2016.03.019. Epub 2016 Mar 16.
Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nanoparticles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano-biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organo-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system.
介孔硅材料具有有机桥联的硅倍半氧烷骨架，是无机硅、介孔和有机物的协同组合，与具有纯 Si-O 组成的传统介孔硅材料相比，具有一些新颖或增强的物理化学和生物相容性特性。随着纳米技术的快速发展，最近分别从 100%或更少的桥联有机硅前体合成了单分散纳米级周期性介孔有机硅纳米颗粒（PMO NPs）和有机桥联介孔硅纳米颗粒（MSNs），具有各种有机基团和结构。此后，这些材料被用作载体平台，构建用于纳米生物医学应用的生物成像和/或治疗剂递送纳米系统，它们表现出一些独特的和/或增强的特性和性能。本文综述了 PMO NPs 和有机桥联 MSNs 的可控合成、物理化学和生物相容性，以及它们作为生物成像剂和/或治疗剂递送系统在纳米生物医学中的应用。
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