Department of Chemistry and Laboratory of Advanced Materials, Fudan University , Shanghai 200433, P. R. China.
J Am Chem Soc. 2014 Oct 22;136(42):15086-92. doi: 10.1021/ja508733r. Epub 2014 Oct 7.
Multifunctional dual-compartment Janus mesoporous silica nanocomposites of UCNP@SiO2@mSiO2&PMO (UCNP = upconversion nanoparticle, PMO = periodic mesoporous organosilica) containing core@shell@shell structured UCNP@SiO2@mSiO2 nanospheres and PMO single-crystal nanocubes have been successfully synthesized via a novel anisotropic island nucleation and growth approach with the ordered mesostructure. The asymmetric Janus nanocomposites show a very uniform size of 300 nm and high surface area of ~1290 m(2)/g. Most importantly, the Janus nanocomposites possess the unique dual independent mesopores with different pore sizes (2.1 nm and 3.5-5.5 nm) and hydrophobicity/hydrophilicity for loading of multiple guests. The distinct chemical properties of the silica sources and the different mesostructures of the dual-compartments are the necessary prerequisites for the formation of the Janus nanostructure. With the assistance of the near-infrared (NIR) to ultraviolet/visible (UV-vis) optical properties of UCNPs and heat-sensitive phase change materials, the dual-compartment Janus mesoporous silica nanocomposites can be further applied into nanobiomedicine for heat and NIR light bimodal-triggered dual-drugs controllable release. It realizes significantly higher efficiency for cancer cell killing (more than 50%) compared to that of the single-triggered drugs delivery system (25%).
多功能双隔室 Janus 介孔硅纳米复合材料 UCNP@SiO2@mSiO2&PMO（UCNP=上转换纳米粒子，PMO=周期性介孔有机硅），包含核壳结构 UCNP@SiO2@mSiO2 纳米球和 PMO 单晶纳米立方，通过具有有序介孔结构的新型各向异性岛屿成核和生长方法成功合成。不对称 Janus 纳米复合材料具有非常均匀的尺寸约 300nm 和高比表面积约 1290m2/g。最重要的是，Janus 纳米复合材料具有独特的双独立介孔，具有不同的孔径（2.1nm 和 3.5-5.5nm）和疏水性/亲水性，可负载多种客体。硅源的不同化学性质和双隔室的不同介孔结构是 Janus 纳米结构形成的必要前提。借助于上转换纳米粒子的近红外（NIR）到紫外/可见（UV-vis）光学性质和热敏相变材料，双隔室 Janus 介孔硅纳米复合材料可进一步应用于纳米生物医学领域，用于热和近红外光双模态触发的双药物可控释放。与单触发药物输送系统（约 25%）相比，它实现了对癌细胞杀伤的效率显著提高（超过 50%）。
