Ali Naghian Amir Hosein, Hashemi Zahra, Chekin Fereshteh, Saleh Na'il
Department of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University Amol Iran.
Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University Amol Iran
Nanoscale Adv. 2024 Jul 29;6(18):4657-4663. doi: 10.1039/d4na00435c. eCollection 2024 Sep 10.
Ribavirin (RIB) is widely used for the treatment of viral diseases such as herpes, hepatitis C, and Lassa fever. Moreover, to control the spread of COVID-19, the consumption of antiviral medicines, including RIB, has increased significantly worldwide. By combining ordered mesoporous carbon with silica nanoparticles ultrasound, we synthesized silica/ordered mesoporous carbon (SiO-OMC) hybrid composites that show excellent electrochemical performance. The hybrid composite was found to contain spherical SiO nanoparticles having diameters ranging from 21 to 29 nm. A sensor comprising a carbon paste electrode and SiO-OMC (SiO-OMC/CPE) facilitated the ultrasensitive and selective detection of RIB at an oxidation potential of 0.71 V, having a linear range of 0.1-40 μmol L, limit of detection of 0.067 μmol L, and sensitivity of 1.969 μA μmol L. Furthermore, the results indicate that charge transfer at the interface of the SiO-OMC hybrid results in a synergistic effect compared to OMC and SiO alone. The advantages include the potential for regenerating the sensor surface, rapid and facile production, and suitability for the detection of RIB in capsule, human plasma, and urine samples, making SiO-OMC/CPE a promising interface for bioelectrochemical applications.
利巴韦林（RIB）被广泛用于治疗疱疹、丙型肝炎和拉沙热等病毒性疾病。此外，为了控制新型冠状病毒肺炎（COVID-19）的传播，包括RIB在内的抗病毒药物在全球范围内的消费量显著增加。通过将有序介孔碳与二氧化硅纳米颗粒超声相结合，我们合成了具有优异电化学性能的二氧化硅/有序介孔碳（SiO-OMC）杂化复合材料。发现该杂化复合材料包含直径范围为21至29nm的球形SiO纳米颗粒。一种由碳糊电极和SiO-OMC组成的传感器（SiO-OMC/CPE）在0.71V的氧化电位下实现了对RIB的超灵敏和选择性检测，线性范围为0.1 - 40μmol/L，检测限为0.067μmol/L，灵敏度为1.969μA/μmol/L。此外，结果表明，与单独的OMC和SiO相比，SiO-OMC杂化材料界面处的电荷转移产生了协同效应。其优点包括传感器表面具有再生潜力、制备快速简便，并且适用于检测胶囊、人血浆和尿液样本中的RIB，这使得SiO-OMC/CPE成为生物电化学应用中有前景的界面。
